دورية أكاديمية
Expression of Placental Neurotrophin-3 (NT-3) in Physiological Pregnancy, Preeclampsia and Chorioamnionitis.
| العنوان: | Expression of Placental Neurotrophin-3 (NT-3) in Physiological Pregnancy, Preeclampsia and Chorioamnionitis. |
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| المؤلفون: | Casciaro A; Department of Human Pathology and Oncology., Arcuri F, Occhini R, Toti MS, De Felice C, Toti P |
| المصدر: | Clinical medicine. Pathology [Clin Med Pathol] 2009 Jun 11; Vol. 2, pp. 9-15. Date of Electronic Publication: 2009 Jun 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Libertas Academica Country of Publication: New Zealand NLM ID: 101473729 Publication Model: Electronic Cited Medium: Internet ISSN: 1178-1181 (Electronic) Linking ISSN: 11781181 NLM ISO Abbreviation: Clin Med Pathol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Auckland, N. Z.] : Libertas Academica |
| مستخلص: | Neurotrophic factors are a group of proteins that act as paracrine and autocrine growth factors. They are involved in the regulation of morphogenesis and development of several tissues. The present study aims to evaluate, for the first time, the expression of Neurotrophin-3 in the human placenta during normal pregnancy and in preeclampsia and chorioamnionitis. Neurotrophin-3 mRNA, assessed by RT-PCR analysis in six term placentas, were observed in all the specimens examined. Neurotrophin-3 protein expression and tissue distribution was evaluated by immunohistochemistry in placenta samples from uncomplicated first trimester (n = 5) and term (n = 5) pregnancies as well as in specimens from preeclampsia (n = 5) and chorioamnionitis (n = 5). In first trimester specimens, strong immunoreactivity was present in villous stromal cells, in the cyto- and syncytiotrophoblast, in decidua cells and in endometrial glands. Third trimester specimens showed prominent immunostaining in cyto- and syncytiotrophoblast cells, in decidua cells and in the amniotic membranes. Villous stromal cells were weakly stained. Similar protein localization was observed in placentas with preeclampsia and chorioamnionitis. In the latter, however, positive villous stromal cells increased in number and in staining intensity when compared with controls and preeclampsia (p < 0.001). The roles of Neurotrophin-3 in pregnancy are presently unknown. A regulatory function on placenta and foetal brain development and maternal inflammatory response may be hypothesized. |
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| فهرسة مساهمة: | Keywords: chorioamnionitis; neurotrophins; placenta; preeclampsia; pregnancy |
| تواريخ الأحداث: | Date Created: 20101215 Date Completed: 20110714 Latest Revision: 20211020 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC2990238 |
| DOI: | 10.4137/cpath.s2325 |
| PMID: | 21151544 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1178-1181 |
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| DOI: | 10.4137/cpath.s2325 |