دورية أكاديمية
أعرض في EDS

17β-estradiol and progesterone regulate multiple progestin signaling molecules in the anteroventral periventricular nucleus, ventromedial nucleus and sexually dimorphic nucleus of the preoptic area in female rats.

التفاصيل البيبلوغرافية
العنوان: 17β-estradiol and progesterone regulate multiple progestin signaling molecules in the anteroventral periventricular nucleus, ventromedial nucleus and sexually dimorphic nucleus of the preoptic area in female rats.
المؤلفون: Intlekofer KA; Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003, USA., Petersen SL
المصدر: Neuroscience [Neuroscience] 2011 Mar 10; Vol. 176, pp. 86-92. Date of Electronic Publication: 2010 Dec 24.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE
أسماء مطبوعة: Publication: [New York?] : Elsevier Science
Original Publication: Oxford, Elmsford, N. Y., Pergamon Press
مواضيع طبية MeSH: Estradiol/*metabolism , Preoptic Area/*metabolism , Progesterone/*metabolism , Progestins/*metabolism , Reproduction/*physiology , Signal Transduction/*physiology, Animals ; Female ; RNA, Messenger/analysis ; Rats ; Rats, Sprague-Dawley ; Receptors, Progesterone/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
مستخلص: Recent work identified novel progestin signaling molecules, including progesterone receptor membrane component 1 (Pgrmc1), Pgrmc2, serpine mRNA binding protein 1 (Serbp1), progestin and adiponectin receptors 7 (Paqr7) and Paqr8. These molecules mediate rapid progesterone (P(4)) effects in non-neural tissue and we recently mapped their expression in the brain. Many rapid effects of P(4) require 17β-estradiol (E(2)) and P(4) priming; therefore, we examined the effects of ovarian hormones on the expression of these non-classical progestin signaling molecules. We focused specifically on the anteroventral periventricular nucleus (AVPV), the sexually dimorphic nucleus of the preoptic area (SDN-POA) and the ventrolateral portion of the ventromedial nucleus (VMNvl). These brain nuclei are important for female reproduction. Ovariectomized adult female rats were implanted with capsules containing sesame oil or E(2), and injected 48 h later with sesame oil or P(4). Brains were collected 8 h later and RNA was isolated from the AVPV, SDN-POA and VMNvl. We assessed the effects of ovarian hormones on mRNA levels using quantitative polymerase chain reaction (QPCR). In the AVPV, Serbp1 mRNA levels were increased by P(4) in the presence of E(2), and Paqr8 was downregulated by P(4) alone. In the SDN-POA, combined E(2) and P(4) increased Pgrmc1 and Serbp1 mRNA levels, and E(2) alone increased Paqr8 mRNA levels. Finally, in the VMNvl, P(4) increased mRNA levels encoding Pgrmc1, Pgrmc2 and Serbp1, and the combination of E(2) and P(4) increased Pgrmc1 and Serbp1 mRNA levels. Paqr7 was not regulated by E(2) or P(4) in any brain region examined. In summary, we showed that ovarian hormones regulate novel progestin signaling molecules in brain regions important for the neuroendocrine control of reproduction.
(Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved.)
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معلومات مُعتمدة: T32 MH020051 United States MH NIMH NIH HHS; R01 ES008774-03 United States ES NIEHS NIH HHS; ES013885 United States ES NIEHS NIH HHS; R01 HD027305 United States HD NICHD NIH HHS; R21 ES013885 United States ES NIEHS NIH HHS; HD027305 United States HD NICHD NIH HHS; R01 HD027305-15 United States HD NICHD NIH HHS
المشرفين على المادة: 0 (Progestins)
0 (RNA, Messenger)
0 (Receptors, Progesterone)
4G7DS2Q64Y (Progesterone)
4TI98Z838E (Estradiol)
تواريخ الأحداث: Date Created: 20101228 Date Completed: 20110601 Latest Revision: 20211020
رمز التحديث: 20240513
مُعرف محوري في PubMed: PMC3046387
DOI: 10.1016/j.neuroscience.2010.12.033
PMID: 21185909
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-7544
DOI:10.1016/j.neuroscience.2010.12.033