دورية أكاديمية
Pre-morbid Conduct Disorder symptoms are associated with cannabis use among individuals with a first episode of psychosis.
| العنوان: | Pre-morbid Conduct Disorder symptoms are associated with cannabis use among individuals with a first episode of psychosis. |
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| المؤلفون: | Malcolm CP; King's College London, Department of Forensic and Neurodevelopmental Sciences (Box P023), NIHR Biomedical Research Centre, Institute of Psychiatry, King's Health Partners, De Crespigny Park, London SE5 8AF, United Kingdom. charlotte.malcolm@kcl.ac.uk, Picchioni MM, DiForti M, Sugranyes G, Cooke E, Joseph C, McQueen G, Paparelli A, Stilo S, O'Connor J, Morgan C, Murray RM, Hodgins S |
| المصدر: | Schizophrenia research [Schizophr Res] 2011 Mar; Vol. 126 (1-3), pp. 81-6. Date of Electronic Publication: 2010 Dec 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publisher B. V Country of Publication: Netherlands NLM ID: 8804207 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2509 (Electronic) Linking ISSN: 09209964 NLM ISO Abbreviation: Schizophr Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publisher B. V., c1988- |
| مواضيع طبية MeSH: | Conduct Disorder/*complications , Conduct Disorder/*epidemiology , Marijuana Abuse/*complications , Marijuana Abuse/*epidemiology , Psychotic Disorders/*complications , Psychotic Disorders/*epidemiology, Adult ; Age Factors ; Conduct Disorder/psychology ; Female ; Humans ; Male ; Psychiatric Status Rating Scales ; Psychotic Disorders/psychology ; Retrospective Studies ; Risk Factors ; Young Adult |
| مستخلص: | Background: Early cannabis use has consistently been associated with an increased risk for the later development of psychosis. Studies suggest that Conduct Disorder (CD) is more common amongst young people who later go on to develop psychosis. CD has been associated with greater and earlier cannabis use in general population samples. Based on this evidence, we hypothesised that among patients experiencing their first episode of psychosis, the presence of CD symptoms prior to age 15 would be associated with cannabis use. Method: 102 patients experiencing a first episode of psychosis were interviewed to assess CD symptoms prior to age 15 and use of cannabis and other substances. Results: The number of CD symptoms was significantly associated with lifetime cannabis use (odds ratio=5.41 (1.76-16.57), p=0.03) and with first use of cannabis before age 14 (odds ratio=1.46 (1.12-1.92), p=0.006), after controlling for stimulant/hallucinogen use and level of education. Conclusions: Among patients experiencing a first episode of psychosis, CD symptoms were significantly associated with use of cannabis and with use by age 14. Among individuals vulnerable for psychosis, CD symptoms may independently increase the likelihood of cannabis use which in turn increases the risk of psychosis. (Copyright © 2010 Elsevier B.V. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20101228 Date Completed: 20110624 Latest Revision: 20160526 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.schres.2010.11.025 |
| PMID: | 21186097 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-2509 |
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| DOI: | 10.1016/j.schres.2010.11.025 |