دورية أكاديمية
[Effects of exercise on JNK phosphorylation and expression in skeletal muscle of rats].
| العنوان: | [Effects of exercise on JNK phosphorylation and expression in skeletal muscle of rats]. |
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| المؤلفون: | Cao SC; Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, China., Sun LG, Zhao G, Liu HL, Zhang H |
| المصدر: | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology [Zhongguo Ying Yong Sheng Li Xue Za Zhi] 2009 Feb; Vol. 25 (1), pp. 103-6. |
| نوع المنشور: | English Abstract; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo ying yong sheng li xue za zhi bian ji bu Country of Publication: China NLM ID: 9426407 Publication Model: Print Cited Medium: Print ISSN: 1000-6834 (Print) Linking ISSN: 10006834 NLM ISO Abbreviation: Zhongguo Ying Yong Sheng Li Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tianjin : Zhongguo ying yong sheng li xue za zhi bian ji bu Original Publication: Beijing Shi : Zhongguo ying yong sheng li xue za zhi bian ji bu, |
| مواضيع طبية MeSH: | JNK Mitogen-Activated Protein Kinases/*metabolism , Muscle, Skeletal/*metabolism , Physical Conditioning, Animal/*physiology, Animals ; Glucose Tolerance Test ; Insulin/physiology ; JNK Mitogen-Activated Protein Kinases/genetics ; Male ; Phosphorylation ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley |
| مستخلص: | Aim: To investigate the effects of exercise on JNK phosphorylation, protein and gene expression. Methods: Male rats were randomly divided into control and trained groups. The trained rats were submitted to 1 h or 1.5 h of exercise daily and had a fragment of their excised gastrocenemius muscle, 24 h or 48 h after the last training session. The train lasted for 7 weeks. The changes in the expressions of JNK and p-JNK were determined by Western blotting. The expression of JNK mRNA was determined by RT-PCR. Results: Glucose tolerance test found that blood insulin concentration was decreased with exercise training. Exercise led to a marked increase in p-JNK of trained groups 24 hours after exercise in rats that exercised for 1 hour per day and 24 and 48 hours after the exercise in those that exercised for 1.5 hours per day as compared with controls, and the protein expression of JNK significantly increased 24 and 48 hours after the exercise in rats that exercised for 1.5 hours per day. JNK mRNA was increased by exercise 1.5 h/d, 24 h after the last training session. Conclusion: Exercise could increase muscle responsiveness to insulin, improving the total JNK and p-JNK and mRNA expression. |
| المشرفين على المادة: | 0 (Insulin) 0 (RNA, Messenger) EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases) |
| تواريخ الأحداث: | Date Created: 20101229 Date Completed: 20121001 Latest Revision: 20101224 |
| رمز التحديث: | 20231215 |
| PMID: | 21186629 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1000-6834 |
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