دورية أكاديمية
Differential expression of Yes-associated protein is correlated with expression of cell cycle markers and pathologic TNM staging in non-small-cell lung carcinoma.
| العنوان: | Differential expression of Yes-associated protein is correlated with expression of cell cycle markers and pathologic TNM staging in non-small-cell lung carcinoma. |
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| المؤلفون: | Kim JM; Department of Pathology, Daejeon Regional Cancer Center, Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, Republic of Korea., Kang DW, Long LZ, Huang SM, Yeo MK, Yi ES, Kim KH |
| المصدر: | Human pathology [Hum Pathol] 2011 Mar; Vol. 42 (3), pp. 315-23. Date of Electronic Publication: 2010 Dec 28. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: W B Saunders Country of Publication: United States NLM ID: 9421547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8392 (Electronic) Linking ISSN: 00468177 NLM ISO Abbreviation: Hum Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia, PA : W B Saunders Original Publication: Philadelphia, W B. Saunders Co. |
| مواضيع طبية MeSH: | Carcinoma, Non-Small-Cell Lung/*metabolism , Carcinoma, Squamous Cell/*metabolism , Cyclins/*metabolism , ErbB Receptors/*metabolism , Lung Neoplasms/*metabolism , Proto-Oncogene Proteins c-yes/*metabolism, Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/genetics ; Cell Nucleus/metabolism ; Cell Nucleus/pathology ; Diagnostic Imaging ; ErbB Receptors/genetics ; Female ; Gene Amplification ; Gene Dosage ; Humans ; In Situ Hybridization ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Male ; Middle Aged ; Mitogen-Activated Protein Kinase 1/metabolism ; Neoplasm Staging ; Prognosis ; Proto-Oncogene Proteins c-yes/genetics ; Tissue Array Analysis |
| مستخلص: | Yes-associated protein, a downstream effector of the Hippo signaling pathway, has been linked to progression of non-small-cell lung carcinoma. The aim of this study was to investigate expression of Yes-associated protein in lung adenocarcinoma and squamous cell carcinoma. Associations of Yes-associated protein expression with clinicopathologic parameters, expression of cell cycle-specific markers, and epidermal growth factor receptor gene amplification were also analyzed. In a univariate analysis of the 66 adenocarcinomas, high nuclear expression of Yes-associated protein was significantly correlated with expression of cyclin A and mitogen-activated protein kinase. Multivariate analysis, including age and sex, showed that cyclin A expression was independently correlated with nuclear expression of Yes-associated protein in adenocarcinomas. Furthermore, high nuclear expression of Yes-associated protein was also a significant predictor of epidermal growth factor receptor gene amplification for adenocarcinoma. For the 102 squamous cell carcinomas, univariate analysis revealed that high cytoplasmic expression of Yes-associated protein was correlated with the low pathologic TNM staging (stage I) and histologic grading. Multivariate analysis, including age and sex, showed that cytoplasmic expression of Yes-associated protein was an independent predictor of low pathologic TNM staging. These results indicate that nuclear overexpression of Yes-associated protein contributes to pulmonary adenocarcinoma growth and that high cytoplasmic expression of Yes-associated protein is an independent predictor of low pathologic TNM staging and histologic grading. The differential effects of Yes-associated protein expression patterns in adenocarcinomas and squamous cell carcinomas suggest that Yes-associated protein may play important roles in different pathways in distinct tumor subtypes. These observations may, therefore, lead to new perspectives on therapeutic targeting of these tumor types. (Copyright © 2011 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (Cyclins) EC 2.7.10.1 (EGFR protein, human) EC 2.7.10.1 (ErbB Receptors) EC 2.7.10.2 (Proto-Oncogene Proteins c-yes) EC 2.7.10.2 (YES1 protein, human) EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1) |
| تواريخ الأحداث: | Date Created: 20101231 Date Completed: 20110329 Latest Revision: 20181201 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.humpath.2010.08.003 |
| PMID: | 21190720 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-8392 |
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| DOI: | 10.1016/j.humpath.2010.08.003 |