دورية أكاديمية
Influence of the combination of infrared and red laser light on the healing of cutaneous wounds infected by Staphylococcus aureus.
| العنوان: | Influence of the combination of infrared and red laser light on the healing of cutaneous wounds infected by Staphylococcus aureus. |
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| المؤلفون: | Santos NR; Center of Biophotonics, School of Dentistry, Federal University of Bahia (UFBA), Salvador, BA, Brazil., de M Sobrinho JB, Almeida PF, Ribeiro AA, Cangussú MC, dos Santos JN, Pinheiro AL |
| المصدر: | Photomedicine and laser surgery [Photomed Laser Surg] 2011 Mar; Vol. 29 (3), pp. 177-82. Date of Electronic Publication: 2011 Jan 08. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101222340 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8550 (Electronic) Linking ISSN: 15495418 NLM ISO Abbreviation: Photomed Laser Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., c2004-c2018 |
| مواضيع طبية MeSH: | Low-Level Light Therapy/*methods , Staphylococcal Infections/*radiotherapy , Surgical Wound Infection/*radiotherapy , Wound Healing/*physiology, Animals ; Biopsy, Needle ; Combined Modality Therapy ; Disease Models, Animal ; Immunohistochemistry ; Infrared Rays/therapeutic use ; Lasers, Semiconductor/therapeutic use ; Male ; Photomicrography ; Radiation Dosage ; Random Allocation ; Rats ; Rats, Wistar ; Skin/microbiology ; Skin/pathology ; Skin/radiation effects ; Surgical Wound Infection/microbiology ; Treatment Outcome |
| مستخلص: | Aim: We aimed to assess the use of two wavelengths on the healing of infected wounds. Background: Infection is the most significant cause of impaired wound repair or healing. Several therapeutic approaches are used for improving wound healing including the use of different light sources, such as the laser. Some wavelengths yield positive photobiological effects on the healing process. Material and Methods: The backs of 24 young adult male Wistar rats under general anesthesia were shaved and cleaned, and a 1 by 1 cm cutaneous wound was created with a scalpel and left untreated. The wounds were infected with Staphylococcus aureus, and the rats were randomly divided into two sets of four subgroups with three animals in each subgroup: control, red laser light, infrared laser light, and red + infrared laser light. Laser phototherapy was carried out with a diode [λ680 nm/790 nm, power (P) = 30 mW/40 mW, continuous wave laser, Ø = 3 mm, power density (P) = 424 and 566 mW/cm(2), time = 11.8/8.8 sec, E = 0.35 J] and started immediately after surgery and repeated every other day for 7 d. Laser light was applied on four points around the wounded area (5 J/cm(2)). The animals were killed either 8 or 15 d after contamination. Specimens were taken, embedded in paraffin, and sectioned and stained for histological analysis. Results: Histological analysis showed that control subjects had a lower amount of blood vessels when compared with irradiated subjects. Irradiated subjects had more advanced resolution of inflammation compared with controls. Irradiated subjects also showed a more intense expression of the collagen matrix. The collagen fibers were mostly mature and well organized in these subjects at the end of the experimental time especially when both wavelengths were used. Conclusion: The results of the present study indicate that laser phototherapy has a positive effect on the healing of infected wounds, particularly with the association of λ680 + λ790 nm. |
| تواريخ الأحداث: | Date Created: 20110111 Date Completed: 20110719 Latest Revision: 20220317 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1089/pho.2009.2749 |
| PMID: | 21214389 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-8550 |
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| DOI: | 10.1089/pho.2009.2749 |