دورية أكاديمية
Number of stromal precursors in mouse bone marrow and expression of cytokine genes in primary cultures of mouse bone marrow cells during various periods after immunization with S. typhimurium antigens.
| العنوان: | Number of stromal precursors in mouse bone marrow and expression of cytokine genes in primary cultures of mouse bone marrow cells during various periods after immunization with S. typhimurium antigens. |
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| المؤلفون: | Gorskaya UF; Laboratory for Regulation of Immunity, Laboratory for Microbiology of Latent Infections, Laboratory of Cytokines, N F Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow, Russia. Uliya.Gorskaya@nearmedic.ru, Danilova TA, Mesentzeva MV, Shapoval IM, Narovlyansky AN, Nesterenko VG |
| المصدر: | Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2010 Oct; Vol. 149 (4), pp. 425-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English; Russian |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: New York, Consultants Bureau. |
| مواضيع طبية MeSH: | Antigens, Bacterial/*immunology , Bone Marrow Cells/*cytology , Salmonella typhimurium/*immunology , Stromal Cells/*cytology, Animals ; Antigens, Bacterial/genetics ; Bone Marrow Cells/metabolism ; Cytokines/biosynthesis ; Cytokines/genetics ; Immunization ; Interferon-gamma/biosynthesis ; Interferon-gamma/genetics ; Interleukin-1beta/biosynthesis ; Interleukin-1beta/genetics ; Interleukin-6/biosynthesis ; Interleukin-6/genetics ; Mice ; Stromal Cells/immunology ; Tumor Necrosis Factor-alpha/biosynthesis ; Tumor Necrosis Factor-alpha/genetics |
| مستخلص: | Administration of S. typhimurium microbial mass to mice was followed by a significant increase (by 3-4 times) in the efficiency of cloning and number of stromal precursors in the femoral bone marrow. These parameters were maximum on days 1-3, but returned to normal by the 8th-15th day after immunization. As differentiated from intact animals, the expression of genes for proinflammatory cytokines IL-1β (day 1 after immunization), IL-6 (days 1-3), TNF-α (days 1, 3, and 6), and IFN-α (days 1-3) was detected in bone marrow cultures from immunized mice. The expression of genes for IFN-γ, IL-18, and IFN-α was decreased on days 1, 3, and 6 after immunization of animals, respectively. Gene expression for the anti-inflammatory cytokine IL-4 was observed on day 6 after immunization. Therefore, this system was not characterized by a decrease in the immune response of stromal cells. The stromal component of hemopoietic and lymphoid organs has the vector of influences in response to bacterial antigens. This vector is directed to the stimulation and progression, but not to the suppression of immune reactions. Our results indicate that resident stromal cells play a role in the immune response of the body. |
| المشرفين على المادة: | 0 (Antigens, Bacterial) 0 (Cytokines) 0 (Interleukin-1beta) 0 (Interleukin-6) 0 (Tumor Necrosis Factor-alpha) 82115-62-6 (Interferon-gamma) |
| تواريخ الأحداث: | Date Created: 20110115 Date Completed: 20110502 Latest Revision: 20190813 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s10517-010-0961-9 |
| PMID: | 21234434 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1573-8221 |
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| DOI: | 10.1007/s10517-010-0961-9 |