دورية أكاديمية
Arachidonic acid cascade and platelet-activating factor in the network of eye inflammatory mediators: therapeutic implications in uveitis.
| العنوان: | Arachidonic acid cascade and platelet-activating factor in the network of eye inflammatory mediators: therapeutic implications in uveitis. |
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| المؤلفون: | Bazan NG; Louisiana State University, Eye Center, New Orleans., de Abreu MT, Bazan HE, Belfort R Júnior |
| المصدر: | International ophthalmology [Int Ophthalmol] 1990 Oct; Vol. 14 (5-6), pp. 335-44. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Kluwer Country of Publication: Netherlands NLM ID: 7904294 Publication Model: Print Cited Medium: Print ISSN: 0165-5701 (Print) Linking ISSN: 01655701 NLM ISO Abbreviation: Int Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Dordrecht : Kluwer Original Publication: The Hague, Junk. |
| مواضيع طبية MeSH: | Arachidonic Acids/*metabolism , Endophthalmitis/*physiopathology , Platelet Activating Factor/*metabolism , Uveitis/*physiopathology, Animals ; Arachidonic Acid ; Arachidonic Acids/therapeutic use ; Autoimmunity ; Endophthalmitis/drug therapy ; Humans ; Hypersensitivity/immunology ; Inflammation/immunology ; Platelet Activating Factor/therapeutic use ; Uveitis/drug therapy |
| مستخلص: | The cellular and biochemical events triggered by uveitis involve a complex array of cells and a heterogeneous network of mediators of intraocular inflammation. Resident cells are activated and inflammatory cells are recruited. Chemical mediators from the arachidonic acid cascade, prostaglandins, hydroxyeicosatetraenoic acids, and leukotrienes, are formed. Several of these metabolites are modulators of cellular functions, but when generated in sustained, excessive amounts, they contribute to enhanced vascular permeability and to the onset of pathophysiological responses. Another very active membrane-derived mediator is platelet-activating factor. This important mediator of immune and inflammatory responses may play a central role in uveitis due to cell priming, since interleukin-1, tumor necrosis factor, and other as yet unidentified mediators are also being generated. The concomitant accumulation of these networks of mediators in various parts of the uveal tract leads to spreading of the intraocular inflammatory response and cellular damage. At both early and late stages of uveitis, the generation of free radicals is also a major contributor to the impairment of function. Free radicals are generated in two distinct sites: in the oxidative burst of recruited white cells and in free radical formation and lipid peroxidation in resident cells. The identification of the cellular events that lead to the accumulation of networks of mediators of inflammation and their effects has important therapeutic implications in uveitis. |
| Number of References: | 48 |
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| معلومات مُعتمدة: | EY 02377 United States EY NEI NIH HHS; EY04928 United States EY NEI NIH HHS; EY06635 United States EY NEI NIH HHS |
| المشرفين على المادة: | 0 (Arachidonic Acids) 0 (Platelet Activating Factor) 27YG812J1I (Arachidonic Acid) |
| تواريخ الأحداث: | Date Created: 19901001 Date Completed: 19910114 Latest Revision: 20200304 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1007/BF00163553 |
| PMID: | 2123479 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 0165-5701 |
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| DOI: | 10.1007/BF00163553 |