دورية أكاديمية
أعرض في EDS

Discovery pipeline for epigenetically deregulated miRNAs in cancer: integration of primary miRNA transcription.

التفاصيل البيبلوغرافية
العنوان: Discovery pipeline for epigenetically deregulated miRNAs in cancer: integration of primary miRNA transcription.
المؤلفون: Hulf T; Epigenetics Laboratory, Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia., Sibbritt T, Wiklund ED, Bert S, Strbenac D, Statham AL, Robinson MD, Clark SJ
المصدر: BMC genomics [BMC Genomics] 2011 Jan 21; Vol. 12, pp. 54. Date of Electronic Publication: 2011 Jan 21.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164 (Electronic) Linking ISSN: 14712164 NLM ISO Abbreviation: BMC Genomics Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2000-
مواضيع طبية MeSH: Epigenesis, Genetic/*genetics , MicroRNAs/*genetics , Neoplasms/*genetics, Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/genetics ; Humans
مستخلص: Background: Cancer is commonly associated with widespread disruption of DNA methylation, chromatin modification and miRNA expression. In this study, we established a robust discovery pipeline to identify epigenetically deregulated miRNAs in cancer.
Results: Using an integrative approach that combines primary transcription, genome-wide DNA methylation and H3K9Ac marks with microRNA (miRNA) expression, we identified miRNA genes that were epigenetically modified in cancer. We find miR-205, miR-21, and miR-196b to be epigenetically repressed, and miR-615 epigenetically activated in prostate cancer cells.
Conclusions: We show that detecting changes in primary miRNA transcription levels is a valuable method for detection of local epigenetic modifications that are associated with changes in mature miRNA expression.
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المشرفين على المادة: 0 (MicroRNAs)
تواريخ الأحداث: Date Created: 20110125 Date Completed: 20110419 Latest Revision: 20211020
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3037319
DOI: 10.1186/1471-2164-12-54
PMID: 21255435
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2164
DOI:10.1186/1471-2164-12-54