دورية أكاديمية
[Molecular genetic studies of the susceptibility of epidemic influenza A(H1N1) virus strains isolated in the 2006-2009 seasons in Russia to oseltamivir (Tamiflu)].
| العنوان: | [Molecular genetic studies of the susceptibility of epidemic influenza A(H1N1) virus strains isolated in the 2006-2009 seasons in Russia to oseltamivir (Tamiflu)]. |
|---|---|
| المؤلفون: | Beliakova NV, Al'khovskiĭ SV, Shevchenko ES, Prilipov AG, Abramov DD, Kolobukhina LV, Merkulova LN, Trushakova SV, Burtseva EI |
| المصدر: | Voprosy virusologii [Vopr Virusol] 2010 Sep-Oct; Vol. 55 (5), pp. 10-3. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: FBUN T︠S︡NII Ėpidemiologii Rospotrebnadzora Country of Publication: Russia (Federation) NLM ID: 0417337 Publication Model: Print Cited Medium: Print ISSN: 0507-4088 (Print) Linking ISSN: 05074088 NLM ISO Abbreviation: Vopr Virusol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Moskva : FBUN T︠S︡NII Ėpidemiologii Rospotrebnadzora Original Publication: Moskva : Ministerstvo zdravookhranenii︠a︡ SSSR |
| مواضيع طبية MeSH: | Antiviral Agents/*pharmacology , Drug Resistance, Viral/*genetics , Influenza A Virus, H1N1 Subtype/*drug effects , Influenza A Virus, H1N1 Subtype/*genetics , Influenza, Human/*epidemiology , Oseltamivir/*pharmacology, Genes, Viral/genetics ; Humans ; Influenza, Human/drug therapy ; Influenza, Human/virology ; Microbial Sensitivity Tests ; Mutation ; Neuraminidase/genetics ; Polymorphism, Restriction Fragment Length ; Russia/epidemiology ; Viral Proteins/genetics |
| مستخلص: | Oseltamivir (Tamiflu) is recommended by WHO experts as a drug to treat and prevent of influenza and to create stocks if its new pandemic variant occurs. The susceptibility of influenza viruses to oseltamivir was studied by polymerase chain reaction-based techniques detecting specific mutations in the neuraminidase gene. The increase in the number of oseltamivir-resistant influenza viruses, isolated from the Russian Federation, with type 1 neuraminidase H274Y mutation from 49% (2007-20008) to 92% (2008-2009) did not depend on the frequency of oseltamivir use. Full correlation of the results obtained by various techniques allows them to be used to monitor the susceptibility of influenza viruses to oseltamivir. |
| المشرفين على المادة: | 0 (Antiviral Agents) 0 (Viral Proteins) 20O93L6F9H (Oseltamivir) EC 3.2.1.18 (Neuraminidase) |
| تواريخ الأحداث: | Date Created: 20110126 Date Completed: 20110222 Latest Revision: 20161109 |
| رمز التحديث: | 20221213 |
| PMID: | 21260988 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0507-4088 |
|---|