دورية أكاديمية
Optimization of microdermabrasion for controlled removal of stratum corneum.
| العنوان: | Optimization of microdermabrasion for controlled removal of stratum corneum. |
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| المؤلفون: | Andrews SN; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA., Zarnitsyn V, Bondy B, Prausnitz MR |
| المصدر: | International journal of pharmaceutics [Int J Pharm] 2011 Apr 04; Vol. 407 (1-2), pp. 95-104. Date of Electronic Publication: 2011 Jan 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Drug Delivery Systems* , Skin Absorption*, Dermabrasion/*methods, Administration, Cutaneous ; Animals ; Dermabrasion/instrumentation ; Permeability ; Pharmaceutical Preparations/administration & dosage ; Pharmaceutical Preparations/metabolism ; Skin/metabolism ; Swine ; Time Factors |
| مستخلص: | Microdermabrasion has been shown to increase skin permeability for transdermal drug delivery by damaging or removing skin's outer layer, stratum corneum. However, relationships between microdermabrasion parameters and effects on the stratum corneum barrier have not been developed. In this study, we determined the effect of microdermabrasion crystal flow rate, time, and suction pressure applied in both static and dynamic modes on the extent of stratum corneum removal from excised porcine skin. In addition to controlling the depth of tissue removal by microdermabrasion parameters, we also controlled the area of tissue removal by applying a metal mask patterned with 125- or 250-μm holes to selectively expose small spots of tissue to microdermabrasion. We found that the extent of stratum corneum removal depended strongly on the crystal flow rate and exposure time and only weakly on pressure or static/dynamic mode operation. Masking the skin was effective to localize stratum corneum removal to exposed sites. Overall, this study demonstrates that optimized microdermabrasion in combination with a mask can be used to selectively remove stratum corneum with three-dimensional control, which is important to translating this technique into a novel method of transdermal drug delivery. (Copyright © 2011 Elsevier B.V. All rights reserved.) |
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| معلومات مُعتمدة: | R01 EB006369 United States EB NIBIB NIH HHS; R01 EB006369-03 United States EB NIBIB NIH HHS; R01 EB006369-04 United States EB NIBIB NIH HHS; R01 EB006369-05 United States EB NIBIB NIH HHS |
| المشرفين على المادة: | 0 (Pharmaceutical Preparations) |
| تواريخ الأحداث: | Date Created: 20110129 Date Completed: 20110627 Latest Revision: 20211020 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC3050026 |
| DOI: | 10.1016/j.ijpharm.2011.01.034 |
| PMID: | 21272628 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3476 |
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| DOI: | 10.1016/j.ijpharm.2011.01.034 |