دورية أكاديمية
Stereoselective pharmacokinetics of tocainide in human uraemic patients and in healthy subjects.
| العنوان: | Stereoselective pharmacokinetics of tocainide in human uraemic patients and in healthy subjects. |
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| المؤلفون: | McErlane KM; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada., Axelson J, Vaughan R, Kerr CR, Price JD, Igwemezie L, Pillai G |
| المصدر: | European journal of clinical pharmacology [Eur J Clin Pharmacol] 1990; Vol. 39 (4), pp. 373-6. |
| نوع المنشور: | Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 1256165 Publication Model: Print Cited Medium: Print ISSN: 0031-6970 (Print) Linking ISSN: 00316970 NLM ISO Abbreviation: Eur J Clin Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, New York, Springer. |
| مواضيع طبية MeSH: | Lidocaine/*analogs & derivatives , Uremia/*metabolism, Adult ; Female ; Half-Life ; Humans ; Lidocaine/blood ; Lidocaine/pharmacokinetics ; Male ; Metabolic Clearance Rate ; Stereoisomerism ; Tocainide ; Uremia/blood |
| مستخلص: | The disposition of tocainide enantiomers were examined in healthy human subjects and uraemic patients following a single i.v. dose (200 mg) of racemic tocainide hydrochloride. In the healthy subjects, the total body clearance of R(-)-tocainide was significantly greater than that of S(+)-tocainide (2.62 vs 1.70 ml.min-1.kg-1). Renal clearance also favoured R(-)-tocainide and appeared to contribute significantly to the stereoselective total body clearance. The volume of distribution of the enantiomers did not differ significantly. Uraemia produced a marked decrease in the total body clearance with no apparent effect on the volume of distribution of both enantiomers. The S/R ratio for total body clearance decreased significantly from 0.66 in healthy subjects to 0.54 in the uraemics, while the ratio for terminal elimination half-life significantly increased from 1.43 to 1.59. These results indicate that uraemia alters the degree of stereoselectivity in the pharmacokinetic parameters of tocainide enantiomers. |
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| المشرفين على المادة: | 27DXO59SAN (Tocainide) 98PI200987 (Lidocaine) |
| تواريخ الأحداث: | Date Created: 19900101 Date Completed: 19910423 Latest Revision: 20190813 |
| رمز التحديث: | 20221208 |
| DOI: | 10.1007/BF00315413 |
| PMID: | 2127569 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 0031-6970 |
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| DOI: | 10.1007/BF00315413 |