دورية أكاديمية
An in-depth analysis of polymer-analogous conjugation using DMTMM.
| العنوان: | An in-depth analysis of polymer-analogous conjugation using DMTMM. |
|---|---|
| المؤلفون: | Pelet JM; Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA. dap43@cornell.edu, Putnam D |
| المصدر: | Bioconjugate chemistry [Bioconjug Chem] 2011 Mar 16; Vol. 22 (3), pp. 329-37. Date of Electronic Publication: 2011 Feb 10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, c1990- |
| مواضيع طبية MeSH: | Acrylic Resins/*chemistry , Morpholines/*chemistry , Polymethacrylic Acids/*chemistry, Agmatine/chemistry ; Galactosamine/chemistry ; Hydrogen-Ion Concentration ; Ligands ; Magnetic Resonance Spectroscopy ; Structure-Activity Relationship |
| مستخلص: | Combinatorial libraries have become increasingly popular in the field of functional biomaterials. One approach for creating diverse polymer libraries is polymer-analogous conjugation of functional groups to polymer scaffolds. In this study, we show that a water-soluble condensing agent, 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM), can be employed to conjugate two disparate model ligands, d-(+)-galactosamine (Gal) and agmatine (Agm), to the side chains of either poly(methacrylic acid) (pMAA) or poly(acrylic acid) (pAA) at various substitution ratios. The degree of substitution was found to be directly influenced by media pH, polymer concentration, structure of ligands, and polymer precursor. A nearly 2-fold increase in conjugation efficiencies for both ligands to pAA was achieved as compared to pMAA under identical conditions reaching up to 56% and 78% of Gal and Agm of total content, respectively. These two structurally similar polymers showed remarkably different performances, which reveals that the selection of a polymer precursor is crucial for the optimal design of polymeric libraries, particularly when complex structural ligands are involved. The approach employed provides a basis from which larger and more diverse combinatorial libraries of functionalized polymers with multiple moieties can be generated. |
| المشرفين على المادة: | 0 (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride) 0 (Acrylic Resins) 0 (Ligands) 0 (Morpholines) 0 (Polymethacrylic Acids) 25087-26-7 (polymethacrylic acid) 4Q93RCW27E (carbopol 940) 70J407ZL5Q (Agmatine) 7535-00-4 (Galactosamine) |
| تواريخ الأحداث: | Date Created: 20110212 Date Completed: 20110628 Latest Revision: 20161125 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1021/bc100125r |
| PMID: | 21309584 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-4812 |
|---|---|
| DOI: | 10.1021/bc100125r |