دورية أكاديمية
أعرض في EDS

Different miRNA signatures of oral and pharyngeal squamous cell carcinomas: a prospective translational study.

التفاصيل البيبلوغرافية
العنوان: Different miRNA signatures of oral and pharyngeal squamous cell carcinomas: a prospective translational study.
المؤلفون: Lajer CB; Department of Oto-rhino-laryngology, Head and Neck Surgery, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen 2100, Denmark. christel.lajer@rh.regionh.dk, Nielsen FC, Friis-Hansen L, Norrild B, Borup R, Garnæs E, Rossing M, Specht L, Therkildsen MH, Nauntofte B, Dabelsteen S, von Buchwald C
المصدر: British journal of cancer [Br J Cancer] 2011 Mar 01; Vol. 104 (5), pp. 830-40. Date of Electronic Publication: 2011 Feb 15.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
أسماء مطبوعة: Publication: 2002- : London : Nature Publishing Group on behalf of Cancer Research UK
Original Publication: London, Lewis.
مواضيع طبية MeSH: Carcinoma, Squamous Cell/*genetics , MicroRNAs/*biosynthesis , Mouth Neoplasms/*genetics , Pharyngeal Neoplasms/*genetics, Female ; Gene Expression ; Humans ; Male ; Microarray Analysis ; Middle Aged ; Prospective Studies
مستخلص: Background: MicroRNAs (miRNAs) are small non-coding RNAs, which regulate mRNA translation/decay, and may serve as biomarkers. We characterised the expression of miRNAs in clinically sampled oral and pharyngeal squamous cell carcinoma (OSCC and PSCC) and described the influence of human papilloma virus (HPV).
Methods: Biopsies obtained from 51 patients with OSCC/PSCC and 40 control patients were used for microarray analysis. The results were correlated to clinical data and HPV status. Supervised learning by support vector machines was employed to generate a diagnostic miRNA signature.
Results: One hundred and fourteen miRNAs were differentially expressed between OSCC and normal oral epithelium, with the downregulation of miR-375 and upregulation of miR-31 as the most significant aberrations. Pharyngeal squamous cell carcinoma exhibited 38 differentially expressed miRNAs compared with normal pharyngeal epithelium. Differences in the miRNA expression pattern of both normal epithelium and SCC were observed between the oral cavity compared with the pharynx. Human papilloma virus infection revealed perturbations of 21 miRNAs, most significantly in miR-127-3p and miR363. A molecular classifier including 61 miRNAs was generated for OSCC with an accuracy of 93%.
Conclusion: MicroRNAs may serve as useful biomarkers in OSCC and PSCC. The influence of HPV on miRNA may provide a mechanism for the distinct clinical behaviour of HPV-infected tumours.
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المشرفين على المادة: 0 (MicroRNAs)
تواريخ الأحداث: Date Created: 20110218 Date Completed: 20110419 Latest Revision: 20231105
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3048216
DOI: 10.1038/bjc.2011.29
PMID: 21326242
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-1827
DOI:10.1038/bjc.2011.29