Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy.

التفاصيل البيبلوغرافية
العنوان:	Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy.
المؤلفون:	Thom SR; Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068, USA. sthom@mail.med.upenn.edu, Milovanova TN, Yang M, Bhopale VM, Sorokina EM, Uzun G, Malay DS, Troiano MA, Hardy KR, Lambert DS, Logue CJ, Margolis DJ
المصدر:	Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society [Wound Repair Regen] 2011 Mar-Apr; Vol. 19 (2), pp. 149-61.
نوع المنشور:	Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة:	English
بيانات الدورية:	Publisher: Blackwell Science Country of Publication: United States NLM ID: 9310939 Publication Model: Print Cited Medium: Internet ISSN: 1524-475X (Electronic) Linking ISSN: 10671927 NLM ISO Abbreviation: Wound Repair Regen Subsets: MEDLINE
أسماء مطبوعة:	Publication: <2010-> : Malden, MA : Blackwell Science Original Publication: St. Louis, MO : Mosby, c1993-
مواضيع طبية MeSH:	Hyperbaric Oxygenation, Diabetic Foot/therapy , Stem Cells/physiology , Wound Healing/physiology, Biopsy, Needle ; Blood Platelets/enzymology ; Cell Movement ; Diabetic Foot/pathology ; Diabetic Foot/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Nitric Oxide Synthase Type III/blood
مستخلص:	Diabetic patients undergoing hyperbaric oxygen therapies (HBO(2)T) for refractory lower extremity neuropathic ulcers exhibit more than a twofold elevation (p=0.004) in circulating stem cells after treatments and the post-HBO(2)T CD34(+) cell population contains two- to threefold higher levels of hypoxia inducible factors-1, -2, and -3, as well as thioredoxin-1 (p<0.003), than cells present in blood before HBO(2)T. Skin margins obtained from 2-day-old abdominal wounds exhibit higher expression of CD133, CD34, hypoxia inducible factor-1, and Trx-1 vs. margins from refractory lower extremity wounds and expression of these proteins in all wounds is increased due to HBO(2)T (p<0.003). HBO(2)T is known to mobilize bone marrow stem cells by stimulating nitric oxide synthase. We found that nitric oxide synthase activity is acutely increased in patients' platelets following HBO(2)T and remains elevated for at least 20 hours. We conclude that HBO(2) T stimulates vasculogenic stem cell mobilization from bone marrow of diabetics and more cells are recruited to skin wounds. (© 2011 by the Wound Healing Society.)
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معلومات مُعتمدة:	K24-AR002212 United States AR NIAMS NIH HHS; R29-DK080376 United States DK NIDDK NIH HHS; R21 DK080376-02 United States DK NIDDK NIH HHS; R21 DK080376 United States DK NIDDK NIH HHS; K24 AR002212 United States AR NIAMS NIH HHS
المشرفين على المادة:	EC 1.14.13.39 (Nitric Oxide Synthase Type III)
تواريخ الأحداث:	Date Created: 20110303 Date Completed: 20110628 Latest Revision: 20211020
رمز التحديث:	20240628
مُعرف محوري في PubMed:	PMC3086729
DOI:	10.1111/j.1524-475X.2010.00660.x
PMID:	21362081
قاعدة البيانات:	MEDLINE

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تدمد:	1524-475X
DOI:	10.1111/j.1524-475X.2010.00660.x