دورية أكاديمية
أعرض في EDS

Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses.

التفاصيل البيبلوغرافية
العنوان: Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses.
المؤلفون: Shinya K; Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan. kyoko.tanaka@aioros.ocn.ne.jp, Okamura T, Sueta S, Kasai N, Tanaka M, Ginting TE, Makino A, Eisfeld AJ, Kawaoka Y
المصدر: Virology journal [Virol J] 2011 Mar 04; Vol. 8, pp. 97. Date of Electronic Publication: 2011 Mar 04.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101231645 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-422X (Electronic) Linking ISSN: 1743422X NLM ISO Abbreviation: Virol J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2004-
مواضيع طبية MeSH: Influenza A virus/*physiology , Influenza, Human/*immunology , Influenza, Human/*prevention & control , Toll-Like Receptor 2/*immunology , Toll-Like Receptor 4/*immunology, Animals ; Cell Line ; Dogs ; Humans ; Influenza A virus/pathogenicity ; Influenza, Human/virology ; Mice ; Mice, Inbred BALB C ; Virulence
مستخلص: Since the beginning of the 20th century, humans have experienced four influenza pandemics, including the devastating 1918 'Spanish influenza'. Moreover, H5N1 highly pathogenic avian influenza (HPAI) viruses are currently spreading worldwide, although they are not yet efficiently transmitted among humans. While the threat of a global pandemic involving a highly pathogenic influenza virus strain looms large, our mechanisms to address such a catastrophe remain limited. Here, we show that pre-stimulation of Toll-like receptors (TLRs) 2 and 4 increased resistance against influenza viruses known to induce high pathogenicity in animal models. Our data emphasize the complexity of the host response against different influenza viruses, and suggest that TLR agonists might be utilized to protect against lethality associated with highly pathogenic influenza virus infection in humans.
References: Cell. 2008 Apr 18;133(2):235-49. (PMID: 18423196)
Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1356-61. (PMID: 14745020)
N Engl J Med. 2009 Aug 13;361(7):680-9. (PMID: 19564631)
Mayo Clin Proc. 2010 Sep;85(9):798-805. (PMID: 20664021)
Lancet. 2004 Feb 21;363(9409):617-9. (PMID: 14987888)
Nat Med. 2006 Oct;12(10):1203-7. (PMID: 16964257)
PLoS One. 2009;4(1):e4176. (PMID: 19137067)
J Infect Dis. 2002 Nov 1;186(9):1199-206. (PMID: 12402188)
Vaccine. 2007 Nov 19;25(47):8067-76. (PMID: 17919786)
Clin Infect Dis. 2006 Sep 15;43(6):748-56. (PMID: 16912951)
Nature. 2004 Oct 7;431(7009):703-7. (PMID: 15470432)
Lancet. 1998 Feb 14;351(9101):467-71. (PMID: 9482437)
Nat Rev Immunol. 2008 Jul;8(7):559-68. (PMID: 18575461)
J Immunol. 2003 Aug 1;171(3):1133-9. (PMID: 12874198)
Nat Immunol. 2000 Nov;1(5):398-401. (PMID: 11062499)
Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9345-50. (PMID: 10430945)
Am J Respir Cell Mol Biol. 2004 Aug;31(2):241-5. (PMID: 15044215)
Curr Pharm Des. 2009;15(11):1269-74. (PMID: 19355966)
PLoS Pathog. 2007 Oct 5;3(10):1374-9. (PMID: 17922570)
Am J Chin Med. 2008;36(6):1171-83. (PMID: 19051344)
J Med Virol. 2001 Mar;63(3):242-6. (PMID: 11170064)
Vaccine. 2007 Apr 20;25(16):3175-8. (PMID: 17280757)
Arch Virol. 1994;136(3-4):439-46. (PMID: 8031247)
J Virol. 2001 Nov;75(22):10730-7. (PMID: 11602714)
Nature. 2007 Jan 18;445(7125):319-23. (PMID: 17230189)
JAMA. 2009 Nov 4;302(17):1880-7. (PMID: 19822626)
Infect Immun. 2005 May;73(5):3044-52. (PMID: 15845512)
المشرفين على المادة: 0 (Toll-Like Receptor 2)
0 (Toll-Like Receptor 4)
تواريخ الأحداث: Date Created: 20110308 Date Completed: 20110713 Latest Revision: 20220311
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3061943
DOI: 10.1186/1743-422X-8-97
PMID: 21375734
قاعدة البيانات: MEDLINE
الوصف
تدمد:1743-422X
DOI:10.1186/1743-422X-8-97