دورية أكاديمية
[On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines].
| العنوان: | [On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines]. |
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| المؤلفون: | Ostrovskaia RU, Vakhitova IuV, Salimgareeva MKh, Iamidanov RS, Sadovnikov SV, Kapitsa IG, Seredenin SB |
| المصدر: | Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2010 Dec; Vol. 73 (12), pp. 2-5. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izd-vo Meditsina Country of Publication: Russia (Federation) NLM ID: 9215981 Publication Model: Print Cited Medium: Print ISSN: 0869-2092 (Print) Linking ISSN: 08692092 NLM ISO Abbreviation: Eksp Klin Farmakol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izd-vo Meditsina |
| مواضيع طبية MeSH: | Brain/*metabolism , Brain-Derived Neurotrophic Factor/*biosynthesis , Dipeptides/*pharmacology , Mitogen-Activated Protein Kinase Kinases/*biosynthesis , Nerve Growth Factor/*biosynthesis , Neuroprotective Agents/*pharmacology , Nootropic Agents/*pharmacology, Animals ; Brain Chemistry/drug effects ; Gene Expression Regulation/drug effects ; Male ; Rats ; Rats, Wistar |
| مستخلص: | The influence of noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111)--a drug combining the nootrope and neuroprotector properties--on the activity of mitogen-activated protein kinases (MAPKs) and the level of NGF and BDNF gene and protein expression in the frontal cortex, hippocampus, and hypothalamus has been studied in rats. Under conditions of chronic administration (28 days, 0.5 mg/day, i.p.), noopept decreased the activity of stress-induced kinases (SAPK/JNK 46/54 and pERK1/2) in rat hippocampus and increases the level of mRNA of the BDNF gene in both hypothalamus and hippocampus. The content of BDNF protein in the hypothalamus was also somewhat increased. In the context of notions about the activation of stress-induced kinases, as an important factor of amyloidogenesis and tau-protein deposition in brain tissue, and the role of deficiency of the neurotrophic factors in the development of neurodegenerative processes, the observed decrease in the activity of stress-activated MAPKs and increased expression of BDNF as a result of noopept administration suggest thatthis drug hasaspecific activity withrespect to some pathogenetic mechanisms involved in the Alzheimer disease. |
| المشرفين على المادة: | 0 (Brain-Derived Neurotrophic Factor) 0 (Dipeptides) 0 (Neuroprotective Agents) 0 (Nootropic Agents) 4QBJ98683M (ethyl phenylacetyl-Pro-Gly) 9061-61-4 (Nerve Growth Factor) EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases) |
| تواريخ الأحداث: | Date Created: 20110315 Date Completed: 20110406 Latest Revision: 20171116 |
| رمز التحديث: | 20240628 |
| PMID: | 21395007 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0869-2092 |
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