دورية أكاديمية
[Resistant hypercholesteremia in clinical practice: new insight into the causes and methods of treatment].
| العنوان: | [Resistant hypercholesteremia in clinical practice: new insight into the causes and methods of treatment]. |
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| المؤلفون: | Kuchmin AN, Chernov SA, Teslia AN, Cherkashin DV, Shulenin KS, Evsiukov KB, Chursina TV, Steklov VI |
| المصدر: | Voenno-meditsinskii zhurnal [Voen Med Zh] 2010 Nov; Vol. 331 (11), pp. 25-30. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Krasnai︠a︡ zvezda Country of Publication: Russia (Federation) NLM ID: 2984871R Publication Model: Print Cited Medium: Print ISSN: 0026-9050 (Print) Linking ISSN: 00269050 NLM ISO Abbreviation: Voen Med Zh Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Moskva : Krasnai︠a︡ zvezda Original Publication: Moskva : Gos. izd-vo med. lit-ry |
| مواضيع طبية MeSH: | Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use , Hypercholesterolemia/*drug therapy , Thyroxine/*therapeutic use, Adult ; Cardiovascular Diseases/prevention & control ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hypercholesterolemia/blood ; Hypercholesterolemia/complications ; Lipids/blood ; Military Personnel ; Severity of Illness Index ; Thyroid Hormones/blood ; Thyroxine/administration & dosage ; Thyroxine/adverse effects |
| مستخلص: | Coronary heart disease and other diseases caused by atherosclerosis, take first place among the causes of adult mortality. Leading role in the development of atherosclerosis belongs to violations of cholesterol metabolism. Reducing mortality from ischemic heart disease primarily associated with adequate correction of the lipid metabolism. The research of the possible causes and correction of resistant hypercholesterolemia is done. Determined that some patients with resistant to statins hypercholesteremia and normal or elevated levels of hormones T3 and T4 in the blood have isolated symptoms of hypothyroidism, which may be a manifestation of reducing tissue sensitivity to thyroid hormones. Adding to the statins levothyroxine in daily doses of 25-50 mkg have additional cholesterol reducing action, allowing to achieve target levels of lipoprotein in blood in patients. The use of levothyroxine in low doses in combination with statins is highly effective and economically justified. |
| المشرفين على المادة: | 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) 0 (Lipids) 0 (Thyroid Hormones) Q51BO43MG4 (Thyroxine) |
| تواريخ الأحداث: | Date Created: 20110315 Date Completed: 20110404 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| PMID: | 21395156 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0026-9050 |
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