دورية أكاديمية
Prevalence of the 1.8 kb complement factor H mRNA in human lung.
| العنوان: | Prevalence of the 1.8 kb complement factor H mRNA in human lung. |
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| المؤلفون: | Demares MJ; INSERM U78, Bois-Guilleurne, France., Davrinche C |
| المصدر: | Immunology [Immunology] 1990 Jun; Vol. 70 (2), pp. 150-4. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0374672 Publication Model: Print Cited Medium: Print ISSN: 0019-2805 (Print) Linking ISSN: 00192805 NLM ISO Abbreviation: Immunology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Blackwell Scientific Publications |
| مواضيع طبية MeSH: | Complement C3b Inactivator Proteins/*genetics , Lung/*immunology , RNA, Messenger/*analysis, Blotting, Northern ; Complement C3b Inactivator Proteins/biosynthesis ; Complement Factor H ; DNA Probes ; Humans ; Liver/analysis ; Lung/analysis |
| مستخلص: | Human complement factor H, described as a 155,000 molecular weight (MW) component, is a key factor in the control of the alternative pathway of complement activation. Using two human factor H cDNA clones, designated R2a (a clone derived from the 3' end of the factor H coding sequence) and B38-1 (a clone derived from the 5' end of the factor H coding sequence), as probes, three factor H-specific transcripts of 4.3 kb, 1.8 kb and 1.5 kb are usually detected in human liver, in equal abundance. Using these two factor H cDNAs to probe human lung RNA, there was evidence of a singular distribution of the factor H mRNA species in human lung compared to liver, in equal prevalence of the 1.8 kb factor H mRNA over the 4.3 kb factor H mRNA (a three- to fourfold difference). No significant expression of the 1.5 kb mRNA was detected. The prevalence of the 1.8 kb complement factor H mRNA leads to the speculation that the predominant factor H form biosynthesized in lung tissue is a truncated form of the factor H molecule. |
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| المشرفين على المادة: | 0 (CFH protein, human) 0 (Complement C3b Inactivator Proteins) 0 (DNA Probes) 0 (RNA, Messenger) 80295-65-4 (Complement Factor H) |
| تواريخ الأحداث: | Date Created: 19900601 Date Completed: 19900828 Latest Revision: 20210514 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC1384185 |
| PMID: | 2142672 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0019-2805 |
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