دورية أكاديمية
Impact of dental care in the prevention of bisphosphonate-associated osteonecrosis of the jaw: a single-center clinical experience.
| العنوان: | Impact of dental care in the prevention of bisphosphonate-associated osteonecrosis of the jaw: a single-center clinical experience. |
|---|---|
| المؤلفون: | Vandone AM; Department of Medical Oncology and Hematology, C.O.E.S. Subalpine OncoHematology Cancer Center. Electronic address: mailto:anna.vandone@libero.it., Donadio M; Department of Medical Oncology and Hematology, C.O.E.S. Subalpine OncoHematology Cancer Center., Mozzati M; Department of Oral Surgery, San Giovanni Battista Molinette Hospital, Turin, Italy., Ardine M; Department of Medical Oncology and Hematology, C.O.E.S. Subalpine OncoHematology Cancer Center., Polimeni MA; Department of Medical Oncology and Hematology, C.O.E.S. Subalpine OncoHematology Cancer Center., Beatrice S; Department of Medical Oncology and Hematology, C.O.E.S. Subalpine OncoHematology Cancer Center., Ciuffreda L; Department of Medical Oncology and Hematology, C.O.E.S. Subalpine OncoHematology Cancer Center., Scoletta M; Department of Oral Surgery, San Giovanni Battista Molinette Hospital, Turin, Italy. |
| المصدر: | Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2012 Jan; Vol. 23 (1), pp. 193-200. Date of Electronic Publication: 2011 Mar 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9007735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-8041 (Electronic) Linking ISSN: 09237534 NLM ISO Abbreviation: Ann Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : London : Elsevier Original Publication: Dordrecht ; Boston : Kluwer Academic Publishers, c1990- |
| مواضيع طبية MeSH: | Bisphosphonate-Associated Osteonecrosis of the Jaw/*prevention & control , Bone Density Conservation Agents/*adverse effects , Dental Care/*methods , Diphosphonates/*adverse effects, Adult ; Aged ; Aged, 80 and over ; Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Female ; Humans ; Male ; Middle Aged ; Risk Factors |
| مستخلص: | Background: Osteonecrosis of the jaw (ONJ) is associated with bisphosphonate (BP) therapy and invasive dental care. An Interdisciplinary Care Group (ICG) was created to evaluate dental risk factors and the efficacy of a preventive restorative dental care in the reduction of ONJ risk. Patients and Methods: This prospective single-center study included patients with bone metastases from solid tumors. Patients who received at least one BP infusion between October 2005 and 31 August 2009 underwent one or more ICG evaluation and regular dental examinations. We also retrospectively evaluated patients with bone metastases from solid tumors who did not undergo dental preventive measures. Results: Of 269 patients, 211 had received at least one infusion of BP therapy: 62% were BP naive and 38% had previous BP exposure. Of these 211 patients followed for 47 months, 6 patients developed ONJ (2.8%). Of 200 patients included in the retrospective analysis, 11 patients developed ONJ (5.5%). Conclusions: In comparison with published ONJ rates and those extrapolated from the retrospective analysis, the observed ONJ rate in the prospective group was lower, suggesting that implementation of a preventive dental program may reduce the risk of ONJ in metastatic patients treated with i.v. BP therapy. |
| المشرفين على المادة: | 0 (Bone Density Conservation Agents) 0 (Diphosphonates) |
| تواريخ الأحداث: | Date Created: 20110324 Date Completed: 20120411 Latest Revision: 20240229 |
| رمز التحديث: | 20240229 |
| DOI: | 10.1093/annonc/mdr039 |
| PMID: | 21427065 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1569-8041 |
|---|---|
| DOI: | 10.1093/annonc/mdr039 |