دورية أكاديمية
Diphenyl diselenide induces anxiolytic-like and sedative effects on the chick social separation-stress behavior.
| العنوان: | Diphenyl diselenide induces anxiolytic-like and sedative effects on the chick social separation-stress behavior. |
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| المؤلفون: | Prigol M; Programa de Pós-graduação em Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil. marinaprigol@yahoo.com.br, Luchese C, Pinton S, Ferreira M, Santos JP, Karkow AK, Mortari AC, Nogueira CW |
| المصدر: | Neuroscience letters [Neurosci Lett] 2011 May 16; Vol. 495 (2), pp. 140-3. Date of Electronic Publication: 2011 Mar 31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Scientific Publishers Ireland Original Publication: Amsterdam, Elsevier/North-Holland. |
| مواضيع طبية MeSH: | Social Isolation*, Anti-Anxiety Agents/*pharmacology , Benzene Derivatives/*pharmacology , Hypnotics and Sedatives/*pharmacology , Organoselenium Compounds/*pharmacology , Stress, Psychological/*prevention & control, Animals ; Anti-Anxiety Agents/therapeutic use ; Behavior, Animal/drug effects ; Benzene Derivatives/therapeutic use ; Chickens ; Dose-Response Relationship, Drug ; Hypnotics and Sedatives/therapeutic use ; Male ; Organoselenium Compounds/therapeutic use ; Stress, Psychological/psychology |
| مستخلص: | The purpose of this research was to investigate the anxiolytic-like effect of diphenyl diselenide [(PhSe)(2)] on the chick social separation-stress behavior. Male chicks (six day-old) received, per oral route, a single administration of (PhSe)(2) at doses of 1, 10 and 50mg/kg. Thirty minutes after treatment, chicks were submitted to the behavioral tests. The behavioral tests: number of separation-induced distress vocalizations and jumps, time of active wakefulness, time of standing/sitting motionless with eyes open, time of standing motionless with eyes closed and time of sleeping posture, during 10 min, were recorded. (PhSe)(2) at doses of 10 and 50mg/kg reduced the number of vocalizations and jumps and the time of active wakefulness and increased the time of standing/sitting motionless with eyes open of chicks. The sleeping posture time was increased in animals treated with (PhSe)(2) at the dose of 50mg/kg. In conclusion, treatment with (PhSe)(2), in a dose dependent-manner, caused anxiolytic-like and sedative effects in chicks. (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Anti-Anxiety Agents) 0 (Benzene Derivatives) 0 (Hypnotics and Sedatives) 0 (Organoselenium Compounds) 1666-13-3 (diphenyldiselenide) |
| تواريخ الأحداث: | Date Created: 20110330 Date Completed: 20110815 Latest Revision: 20110425 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.neulet.2011.03.057 |
| PMID: | 21443928 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7972 |
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| DOI: | 10.1016/j.neulet.2011.03.057 |