دورية أكاديمية
The African Programme for Onchocerciasis Control: impact on onchocercal skin disease.
| العنوان: | The African Programme for Onchocerciasis Control: impact on onchocercal skin disease. |
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| المؤلفون: | Ozoh GA; Department of Dermatology, University of Nigeria Teaching Hospital, Ituku Ozala, Nigeria., Murdoch ME, Bissek AC, Hagan M, Ogbuagu K, Shamad M, Braide EI, Boussinesq M, Noma MM, Murdoch IE, Sékétéli A, Amazigo UV |
| المصدر: | Tropical medicine & international health : TM & IH [Trop Med Int Health] 2011 Jul; Vol. 16 (7), pp. 875-83. Date of Electronic Publication: 2011 Apr 12. |
| نوع المنشور: | Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9610576 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-3156 (Electronic) Linking ISSN: 13602276 NLM ISO Abbreviation: Trop Med Int Health Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Blackwell Scientific Publications Original Publication: Oxford, UK : Blackwell Science Ltd, c1996- |
| مواضيع طبية MeSH: | Filaricides/*therapeutic use , Ivermectin/*therapeutic use , Onchocerciasis/*drug therapy , Pruritus/*parasitology , Skin Diseases, Parasitic/*drug therapy, Adult ; Aged ; Cameroon ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Nigeria ; Odds Ratio ; Onchocerciasis/complications ; Risk Factors ; Rural Population ; Skin Diseases, Parasitic/complications ; Sudan ; Uganda |
| مستخلص: | Objectives: To assess the long-term impact of the African Programme for Onchocerciasis Control on itching and onchocercal skin disease (OSD). Methods: Seven study sites in Cameroon, Sudan, Nigeria and Uganda participated. Two cross-sectional surveys were conducted of communities meso- and hyper-endemic for onchocerciasis before and after 5 or 6 years of community-directed treatment with ivermectin (CDTI). Individuals were asked about any general health symptoms including itching and underwent full cutaneous examinations. Onchocercal skin lesions were documented according to a standard classification. Results: Five thousand one hundred and ninety three people were examined in phase I and 5,180 people in phase II. The presence of onchocercal nodules was a strongly significant (P < 0·001) risk factor for all forms of onchocercal skin disease: APOD (OR 1·66); CPOD (OR 2·84); LOD (OR 2·68); reactive skin lesions (OR 2·38) and depigmentation (OR 3·36). The effect of community-directed treatment with ivermectin was profound. At phase II, there were significant (P < 0·001) reductions in the odds of itching (OR 0·32), APOD (OR 0·28); CPOD (OR 0·34); reactive skin lesions (OR 0·33); depigmentation (OR 0·31) and nodules (OR 0·37). Reduction in the odds of LOD was also significant (OR 0.54, P < 0.03). Conclusions: This first multi-country report of the long-term impact of CDTI reveals a substantial reduction in itching and OSD. APOC operations are having a major effect in improving skin health in poor rural populations in Africa. (© 2011 Blackwell Publishing Ltd.) |
| المشرفين على المادة: | 0 (Filaricides) 70288-86-7 (Ivermectin) |
| تواريخ الأحداث: | Date Created: 20110413 Date Completed: 20121001 Latest Revision: 20220409 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/j.1365-3156.2011.02783.x |
| PMID: | 21481109 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-3156 |
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| DOI: | 10.1111/j.1365-3156.2011.02783.x |