دورية أكاديمية
أعرض في EDS

Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division.

التفاصيل البيبلوغرافية
العنوان: Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division.
المؤلفون: Chang JT; Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. changj@ucsd.edu, Ciocca ML, Kinjyo I, Palanivel VR, McClurkin CE, Dejong CS, Mooney EC, Kim JS, Steinel NC, Oliaro J, Yin CC, Florea BI, Overkleeft HS, Berg LJ, Russell SM, Koretzky GA, Jordan MS, Reiner SL
المصدر: Immunity [Immunity] 2011 Apr 22; Vol. 34 (4), pp. 492-504. Date of Electronic Publication: 2011 Apr 14.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge, MA : Cell Press
Original Publication: Cambridge, Mass. : Cell Press, c1994-
مواضيع طبية MeSH: Mitosis*, Proteasome Endopeptidase Complex/*metabolism , T-Box Domain Proteins/*immunology , T-Lymphocytes/*cytology , T-Lymphocytes/*immunology, Animals ; Cell Polarity ; Cells, Cultured ; Mice ; Mice, Inbred C57BL ; Phosphorylation ; T-Box Domain Proteins/metabolism ; T-Lymphocytes/enzymology
مستخلص: Polarized segregation of proteins in T cells is thought to play a role in diverse cellular functions including signal transduction, migration, and directed secretion of cytokines. Persistence of this polarization can result in asymmetric segregation of fate-determining proteins during cell division, which may enable a T cell to generate diverse progeny. Here, we provide evidence that a lineage-determining transcription factor, T-bet, underwent asymmetric organization in activated T cells preparing to divide and that it was unequally partitioned into the two daughter cells. This unequal acquisition of T-bet appeared to result from its asymmetric destruction during mitosis by virtue of concomitant asymmetric segregation of the proteasome. These results suggest a mechanism by which a cell may unequally localize cellular activities during division, thereby imparting disparity in the abundance of cell fate regulators in the daughter cells.
(Copyright © 2011 Elsevier Inc. All rights reserved.)
التعليقات: Comment in: Nat Rev Immunol. 2011 Jun;11(6):367. (PMID: 21597476)
References: J Exp Med. 2010 Jun 7;207(6):1235-46. (PMID: 20479114)
J Immunol. 2010 Jul 1;185(1):367-75. (PMID: 20530266)
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3675-80. (PMID: 20133676)
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7732-7. (PMID: 18511557)
Nat Immunol. 2002 Jul;3(7):652-8. (PMID: 12055627)
Biochemistry. 2006 Aug 15;45(32):9639-47. (PMID: 16893165)
Nat Immunol. 2002 Jun;3(6):549-57. (PMID: 12006974)
Cell. 2008 Mar 7;132(5):846-59. (PMID: 18329370)
Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11194-8. (PMID: 1280821)
Immunol Cell Biol. 2009 Feb;87(2):154-8. (PMID: 18982018)
Immunity. 2009 Aug 21;31(2):309-20. (PMID: 19664943)
Nature. 2004 Sep 30;431(7008):527-32. (PMID: 15386021)
Cell. 2009 Apr 17;137(2):295-307. (PMID: 19379695)
Science. 2007 Mar 23;315(5819):1687-91. (PMID: 17332376)
Immunity. 2005 Jun;22(6):737-48. (PMID: 15963788)
Immunity. 2008 Mar;28(3):359-69. (PMID: 18342008)
Chem Biol. 2010 Aug 27;17(8):795-801. (PMID: 20797608)
Nat Immunol. 2001 Dec;2(12):1183-8. (PMID: 11702066)
J Immunol. 2001 Apr 1;166(7):4278-81. (PMID: 11254679)
Immunity. 2007 Aug;27(2):281-95. (PMID: 17723218)
Nat Immunol. 2005 Dec;6(12):1236-44. (PMID: 16273099)
Nature. 1998 Sep 3;395(6697):82-6. (PMID: 9738502)
J Exp Med. 1998 May 18;187(10):1721-7. (PMID: 9584150)
J Exp Med. 2008 Sep 29;205(10):2309-18. (PMID: 18809713)
Nature. 2006 Sep 28;443(7110):462-5. (PMID: 17006514)
J Exp Med. 2007 Sep 3;204(9):2015-21. (PMID: 17698591)
Cell. 2008 Feb 22;132(4):583-97. (PMID: 18295577)
Immunity. 2009 Oct 16;31(4):587-97. (PMID: 19818650)
Immunity. 2009 Aug 21;31(2):296-308. (PMID: 19664941)
Nature. 2005 Sep 8;437(7056):275-80. (PMID: 16094321)
J Exp Med. 2006 Sep 4;203(9):2095-107. (PMID: 16923851)
J Exp Med. 2010 Nov 22;207(12):2733-49. (PMID: 21041455)
Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9866-71. (PMID: 15987782)
Nat Immunol. 2006 Mar;7(3):247-55. (PMID: 16444260)
Science. 2002 Jan 11;295(5553):336-8. (PMID: 11786643)
Immunity. 1999 Oct;11(4):399-409. (PMID: 10549622)
Immunity. 2010 Sep 24;33(3):412-23. (PMID: 20850354)
Immunity. 2009 Aug 21;31(2):283-95. (PMID: 19664942)
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15137-42. (PMID: 11752460)
Cancer Res. 2005 Feb 15;65(4):1433-41. (PMID: 15735031)
Nat Immunol. 2011 Jan;12(1):96-104. (PMID: 21151104)
Immunity. 2006 Jul;25(1):79-91. (PMID: 16860759)
Blood. 2010 Dec 16;116(25):5548-59. (PMID: 20847203)
Nat Rev Immunol. 2007 Jun;7(6):479-85. (PMID: 17479128)
Cell. 2000 Mar 17;100(6):655-69. (PMID: 10761931)
Science. 2005 Jan 21;307(5708):430-3. (PMID: 15662016)
Curr Biol. 2004 Aug 24;14(16):R674-85. (PMID: 15324689)
Science. 2002 Jan 11;295(5553):338-42. (PMID: 11786644)
Cell. 1995 Oct 6;83(1):29-38. (PMID: 7553870)
Immunity. 2007 Dec;27(6):985-97. (PMID: 18082432)
معلومات مُعتمدة: K01 AR052802 United States AR NIAMS NIH HHS; R01 AI037584 United States AI NIAID NIH HHS; P01 CA093615-07 United States CA NCI NIH HHS; R01 AI046564-05 United States AI NIAID NIH HHS; P01 CA093615-06 United States CA NCI NIH HHS; K08 DK080949-03 United States DK NIDDK NIH HHS; R01 AI042370 United States AI NIAID NIH HHS; R01 AI046564 United States AI NIAID NIH HHS; R01 AI076458-03 United States AI NIAID NIH HHS; GM053256 United States GM NIGMS NIH HHS; AI061699 United States AI NIAID NIH HHS; R01 AI076458 United States AI NIAID NIH HHS; K01 AR052802-04 United States AR NIAMS NIH HHS; R56 AI076458 United States AI NIAID NIH HHS; R01 AI042370-13 United States AI NIAID NIH HHS; AI37584 United States AI NIAID NIH HHS; T32 AI055428 United States AI NIAID NIH HHS; R24 DK080506 United States DK NIDDK NIH HHS; DK80506 United States DK NIDDK NIH HHS; P01 CA093615 United States CA NCI NIH HHS; R01 AI076458-04 United States AI NIAID NIH HHS; R37 GM053256-15 United States GM NIGMS NIH HHS; T32 HD007516 United States HD NICHD NIH HHS; K08 DK080949 United States DK NIDDK NIH HHS; R01 GM053256 United States GM NIGMS NIH HHS; R01 AI042370-14 United States AI NIAID NIH HHS; T32HD007516 United States HD NICHD NIH HHS; K08 DK080949-04 United States DK NIDDK NIH HHS; R01 AI061699-05 United States AI NIAID NIH HHS; R01 AI076458-05 United States AI NIAID NIH HHS; DK080949 United States DK NIDDK NIH HHS; AI46564 United States AI NIAID NIH HHS; CA093615 United States CA NCI NIH HHS; AI076458 United States AI NIAID NIH HHS; R01 AI042370-15 United States AI NIAID NIH HHS; R37 GM053256-14 United States GM NIGMS NIH HHS; R01 AI084987 United States AI NIAID NIH HHS; R01 AI046564-04 United States AI NIAID NIH HHS; R37 GM053256 United States GM NIGMS NIH HHS; K08 DK080949-05 United States DK NIDDK NIH HHS; AR052802 United States AR NIAMS NIH HHS; K01 AR052802-05 United States AR NIAMS NIH HHS; R01 AI061699 United States AI NIAID NIH HHS; AI042370 United States AI NIAID NIH HHS; R01 AI037584-12 United States AI NIAID NIH HHS; R01 AI037584-11A1 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (T-Box Domain Proteins)
0 (T-box transcription factor TBX21)
EC 3.4.25.1 (Proteasome Endopeptidase Complex)
تواريخ الأحداث: Date Created: 20110419 Date Completed: 20110617 Latest Revision: 20211020
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3088519
DOI: 10.1016/j.immuni.2011.03.017
PMID: 21497118
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-4180
DOI:10.1016/j.immuni.2011.03.017