دورية أكاديمية
Placental alkaline phosphatase in pediatric adrenocortical cancer.
| العنوان: | Placental alkaline phosphatase in pediatric adrenocortical cancer. |
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| المؤلفون: | Boechat GA; Center for Molecular Genetics and Cancer Research in Children (CEGEMPAC), Agostinho Leão Júnior, Brazil., Stinghen ST, Custódio G, Pianovski MA, Figueiredo FR, Jenkins J, Zambetti GP, Ribeiro RC, Figueiredo BC |
| المصدر: | Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2011 May; Vol. 33 (4), pp. e149-53. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505928 Publication Model: Print Cited Medium: Internet ISSN: 1536-3678 (Electronic) Linking ISSN: 10774114 NLM ISO Abbreviation: J Pediatr Hematol Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: New York, NY : Raven Press, c1995- |
| مواضيع طبية MeSH: | Adrenal Cortex/*embryology , Adrenal Cortex/*metabolism , Adrenal Cortex Neoplasms/*metabolism , Adrenal Cortex Neoplasms/*pathology , Alkaline Phosphatase/*metabolism , Isoenzymes/*metabolism, Adrenal Cortex Neoplasms/genetics ; Apoptosis/physiology ; Child ; Female ; GPI-Linked Proteins/metabolism ; Germ-Line Mutation ; Humans ; Immunohistochemistry ; Male ; Tumor Suppressor Protein p53/genetics |
| مستخلص: | The germline R337H mutation in the TP53 gene is considered to be responsible for the increased incidence of adrenocortical tumors (ACTs) in children from Brazil. High level production of hormones in ACTs (>95%) cause virilization alone (60%), Cushing syndrome (<5%), the mixed type (30%), or other rarer manifestations. ACT probably develops owing to events occurring during the final stages of intrauterine life based on the very common early onset of signs and symptoms shortly after birth. In this study, we determined by immunohistochemistry and enzyme assays whether placental alkaline phosphatase (PLAP) is expressed in pediatric ACTs. Immunohistochemical analysis revealed positive p53 expression in 88% of the tested ACTs (29 of 33). PLAP was detected at a slightly lower frequency based on immunohistochemical (17 of 33, 51%) and enzyme activity analyses (9 of 16, 56%). In conclusion, probably at a certain time point during adrenocortical development (end of gestation to early postnatal period), some fetal zone cells survive owing to defective apoptosis and develop into childhood ACT, maintaining some characteristics of the embryonal period, such as PLAP expression. Further studies of PLAP should investigate the functional role, if any, of PLAP in such tumors. |
| المشرفين على المادة: | 0 (GPI-Linked Proteins) 0 (Isoenzymes) 0 (TP53 protein, human) 0 (Tumor Suppressor Protein p53) EC 3.1.3.1 (Alkaline Phosphatase) EC 3.1.3.1 (alkaline phosphatase, placental) |
| تواريخ الأحداث: | Date Created: 20110426 Date Completed: 20110630 Latest Revision: 20111006 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1097/MPH.0b013e3182099a80 |
| PMID: | 21516013 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1536-3678 |
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| DOI: | 10.1097/MPH.0b013e3182099a80 |