دورية أكاديمية
Human papillomavirus genotype distribution in oropharynx and oral cavity cancer in France--The EDiTH VI study.
| العنوان: | Human papillomavirus genotype distribution in oropharynx and oral cavity cancer in France--The EDiTH VI study. |
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| المؤلفون: | St Guily JL; Service d'Oto-rhino-laryngologie et chirurgie cervico-faciale, Hôpital Tenon, Université de Paris 6 et Faculté de Médecine Pierre-et-Marie Curie, Assistance Publique-Hôpitaux de Paris, 4 rue de la Chine, 75970 Paris cedex 20, France. jean.lacau@tnn.aphp.fr, Jacquard AC, Prétet JL, Haesebaert J, Beby-Defaux A, Clavel C, Agius G, Birembaut P, Okaïs C, Léocmach Y, Soubeyrand B, Pradat P, Riethmuller D, Mougin C, Denis F |
| المصدر: | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2011 Jun; Vol. 51 (2), pp. 100-4. Date of Electronic Publication: 2011 May 06. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9815671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5967 (Electronic) Linking ISSN: 13866532 NLM ISO Abbreviation: J Clin Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science, c1998- |
| مواضيع طبية MeSH: | Mouth/*virology , Mouth Neoplasms/*virology , Oropharyngeal Neoplasms/*virology , Oropharynx/*virology , Papillomaviridae/*classification , Papillomavirus Infections/*epidemiology , Papillomavirus Infections/*virology, Female ; France/epidemiology ; Genotype ; Humans ; Male ; Middle Aged ; Mouth Neoplasms/complications ; Oropharyngeal Neoplasms/complications ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/complications ; Prevalence |
| مستخلص: | Background: The incidence of oropharyngeal cancers has gradually increased over the last decades. Recent studies suggest an association between human papillomavirus (HPV) infection and several head and neck cancers, especially oropharyngeal and oral cavity invasive carcinomas. Objectives: The objective was to assess the overall and type specific HPV prevalence in oropharyngeal and oral cavity carcinomas in France. Study Design: Paraffin-embedded tumour specimens were retrospectively collected in 12 French centres and centrally tested for HPV detection and genotyping (INNO-LiPA assay). Results: A total of 523 cases (77% males) were collected, among which 60% were oropharyngeal and 40% oral cavity carcinomas. The most frequent anatomical sites were tonsil (58.9%) and base of tongue (13.7%) for the oropharynx and floor of mouth (41.1%) and oral tongue (38.3%) for the oral cavity. Overall HPV prevalence was 46.5% in oropharyngeal carcinomas and 10.5% in oral cavity carcinomas and was higher in female than in male cases (63.5% vs 42.2% in oropharynx and 17.2% vs 8.0% in oral cavity). About 95% of HPV-positive cases were infected by a single HPV type. HPV 16 was the most prevalent type and was found in 89.7% and 95.5% of HPV-positive oropharyngeal and oral cavity carcinoma cases, respectively. All other HPV types had prevalence below 5%. Conclusions: Our results indicate that HPV is common among oropharyngeal and oral cavity carcinoma cases in France and emphasize the predominance of HPV 16. The potential benefit of HPV vaccination on the occurrence of head and neck carcinomas should be further evaluated. (Copyright © 2011 Elsevier B.V. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20110430 Date Completed: 20110907 Latest Revision: 20220311 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jcv.2011.03.003 |
| PMID: | 21527208 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-5967 |
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| DOI: | 10.1016/j.jcv.2011.03.003 |