دورية أكاديمية
Adrenal steroidogenic function in a black and Hispanic population with precocious pubarche.
| العنوان: | Adrenal steroidogenic function in a black and Hispanic population with precocious pubarche. |
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| المؤلفون: | Oberfield SE; Department of Pediatrics, St. Luke's-Roosevelt Hospital Center, New York, New York 10025., Mayes DM, Levine LS |
| المصدر: | The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 1990 Jan; Vol. 70 (1), pp. 76-82. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Print ISSN: 0021-972X (Print) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Springfield, Ill. : Charles C. Thomas |
| مواضيع طبية MeSH: | Black People* , Hispanic or Latino*, Adrenal Glands/*metabolism , Puberty, Precocious/*metabolism , Steroids/*blood, 3-Hydroxysteroid Dehydrogenases/deficiency ; Adrenal Glands/drug effects ; Adrenal Glands/enzymology ; Adrenocorticotropic Hormone ; Androgens/blood ; Child ; Child, Preschool ; Female ; Hair/growth & development ; Humans ; Hydroxycorticosteroids/blood ; Infant ; Male ; Progestins/blood ; Puberty, Precocious/enzymology ; Black or African American |
| مستخلص: | Adrenal steroidogenic function was evaluated in 34 children with precocious pubarche (PP; onset of pubic hair, less than 8 yr in girls and less than 9 yr in boys). The adrenal steroid response to an iv bolus of ACTH-(1-24) in the patients (aged 9 months to 9 7/12 yr) was compared to that in 16 normal controls (prepubertal, n = 9; Tanner stage II pubic hair, n = 7). The patient population consisted of 20 Hispanics (17 from the Dominican Republic), 13 black Americans, and 1 black Haitian. All patients had normal stimulated levels of 17-hydroxyprogesterone (17-OHP), 11-deoxycortisol (compound S), and desoxycorticosterone, thereby ruling out 21-hydroxylase deficiency and 11 beta-hydroxylase deficiency, respectively. To evaluate for the presence of 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) deficiency, the patients were classified on the basis of their 60-min delta 5-17-hydroxypregnenolone/17-OHP (delta 5-17P/17-OHP) ratio [PP1 (n = 13), less than or equal to 2 SD of Tanner I controls; PP2 (n = 17), greater than 2 SD above Tanner I controls and less than or equal to 2 SD Tanner II controls; and PP3 (n = 4), greater than 2 SD above Tanner II controls; 2.1 +/- 1.0, 6.1 +/- 1.7, and 16.1 +/- 3.3 for PP1, PP2, and PP3, respectively. delta 5-17P/17-OHP for PP1 vs. PP2, PP2 vs. PP3, and PP1 vs. PP3 were significantly different (P less than 0.05) by analysis of variance and multiple comparison testing using the Student-Newman-Keuls procedure. The four patients in PP3 were considered to have a possible nonclassical 3 beta-HSD deficiency. This diagnosis was supported by the fact that these patients had the greatest increment in delta 5-17P and dehydroepiandrosterone (DHEA) levels as well as the highest stimulated delta 5-17P/cortisol (delta 5-17P/F) ratio among the patient groups. In contrast to the ACTH-stimulated androgens there were no differences in the baseline delta 5-17P/170HP or androgens among the patient groups. Additionally, the 60-min delta 5-17P/17-OHP within the patient groups was highly correlated with the 60 min-values for delta 5-17P, DHEA, DHEA/delta 4-androstendione, and delta 5-17P/F. In the children with PP the mean bone age/chronological age (BA/CA) was 1.27 +/- .27, the mean BA/height age (BA/HA) was 1.09 +/- 0.25, and the mean HA/CA was 1.18 +/- 0.17. No differences were noted between the patient population groups in mean BA/CA, mean BA/HA, or mean HA/CA.(ABSTRACT TRUNCATED AT 400 WORDS) |
| المشرفين على المادة: | 0 (Androgens) 0 (Hydroxycorticosteroids) 0 (Progestins) 0 (Steroids) 9002-60-2 (Adrenocorticotropic Hormone) EC 1.1.- (3-Hydroxysteroid Dehydrogenases) |
| تواريخ الأحداث: | Date Created: 19900101 Date Completed: 19900129 Latest Revision: 20240712 |
| رمز التحديث: | 20240712 |
| DOI: | 10.1210/jcem-70-1-76 |
| PMID: | 2152934 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0021-972X |
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| DOI: | 10.1210/jcem-70-1-76 |