دورية أكاديمية
أعرض في EDS

Human leukocyte antigen class II and type 1 diabetes in Latin America: a combined meta-analysis of association and family-based studies.

التفاصيل البيبلوغرافية
العنوان: Human leukocyte antigen class II and type 1 diabetes in Latin America: a combined meta-analysis of association and family-based studies.
المؤلفون: Cifuentes RA; Center for Autoimmune Diseases Research, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia. ricardo.cifuentesgarcia@gmail.com, Rojas-Villarraga A, Anaya JM
المصدر: Human immunology [Hum Immunol] 2011 Jul; Vol. 72 (7), pp. 581-6. Date of Electronic Publication: 2011 Apr 15.
نوع المنشور: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Country of Publication: United States NLM ID: 8010936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1166 (Electronic) Linking ISSN: 01988859 NLM ISO Abbreviation: Hum Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [New York] Elsevier/North-Holland.
مواضيع طبية MeSH: Diabetes Mellitus, Type 1/*genetics , Histocompatibility Antigens Class II/*genetics, Alleles ; Amino Acid Sequence ; Computational Biology ; Diabetes Mellitus, Type 1/immunology ; Epitopes/chemistry ; Epitopes/immunology ; Haplotypes ; Histocompatibility Antigens Class II/immunology ; Humans ; Latin America ; Peptides/chemistry ; Peptides/immunology ; Protein Binding/immunology
مستخلص: Conclusions from association studies could be spurious because of population stratification; therefore we combined association with family studies seeking to confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were associated with type 1 diabetes (T1D) in the admixed Latin America. By calculating the effect summary odds ratios (OR) and their 95% confidence intervals (95% CI), data up to June 2010 showed that risk associations were observed with DRB1*0301-DQA1*0501-DQB1*0201 (odds ratio [OR]: 7.51; 95% confidence interval [CI]: 3.69-15.25) and DQB1*0302 in presence of DRB1*0405 (OR: 11.64; 95% CI: 3.15-43.01) or DRB1*0401 (OR: 5.85; 95% CI: 3.07-11.14). In contrast, DRB1*0404-DQB1*0302 had a nonsignificant TID risk (OR: 2.23; 95% CI: 0.91-5.43). T1D protective associations were observed with DRB1*11-DQA1*0501-DQB1*0301 (OR: 0.24; 95% CI: 0.1-0.56) and DRB1*15-DQA1*0102-DQB1*0602 (OR: 0.35; 95% CI: 0.17-0.73). These results were similar to those observed in Caucasian and other populations, thus highlighting the primary role of class II HLA in T1D regardless of ethnicity. A DRB1*04 risk hierarchy was confirmed with the DRB1*0405 being in the top. A binding prediction analysis disclosed possible receptor-ligand interactions in the HLA-antigenic peptide complex.
(Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
المشرفين على المادة: 0 (Epitopes)
0 (Histocompatibility Antigens Class II)
0 (Peptides)
تواريخ الأحداث: Date Created: 20110507 Date Completed: 20111018 Latest Revision: 20110613
رمز التحديث: 20221213
DOI: 10.1016/j.humimm.2011.03.012
PMID: 21545820
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1166
DOI:10.1016/j.humimm.2011.03.012