دورية أكاديمية
[Pentosan polysulfide sodium for chronic non-bacterial prostatitis in the rat model].
| العنوان: | [Pentosan polysulfide sodium for chronic non-bacterial prostatitis in the rat model]. |
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| المؤلفون: | Li WP; Department of Urology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou, Gansu 730050, China. lwping1979@yahoo.com.cn, Wang YM, Zhang B, Song LM, Qiao GM, Lü XZ |
| المصدر: | Zhonghua nan ke xue = National journal of andrology [Zhonghua Nan Ke Xue] 2011 Apr; Vol. 17 (4), pp. 310-3. |
| نوع المنشور: | English Abstract; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Nanjing Jun Qu Nanjing Zong Yi Yuan zhu ban, Zhonghua Nan Ke Xue Za Zhi Bian Ji Bu bian ji chu ban Country of Publication: China NLM ID: 101093592 Publication Model: Print Cited Medium: Print ISSN: 1009-3591 (Print) Linking ISSN: 10093591 NLM ISO Abbreviation: Zhonghua Nan Ke Xue Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Nanjing : Nanjing Jun Qu Nanjing Zong Yi Yuan zhu ban, Zhonghua Nan Ke Xue Za Zhi Bian Ji Bu bian ji chu ban, |
| مواضيع طبية MeSH: | Pentosan Sulfuric Polyester/*therapeutic use , Prostatitis/*drug therapy, Animals ; Chronic Disease ; Cystitis, Interstitial/drug therapy ; Disease Models, Animal ; Male ; Prostate/pathology ; Prostatitis/pathology ; Rats ; Rats, Sprague-Dawley |
| مستخلص: | Objective: To investigate the therapeutic effect of pentosan polysulfide sodium (PPS) on chronic non-bacterial prostatitis (CNP) in rats. Methods: Based on Robinette's method, we established a CNP model in 80 male SD rats, aged 6 months and weighing 315 - 450 g, by castration followed by subcutaneous injection of estradiol at 0.25 mg / (kg x d) for 30 consecutive days. Then we randomly allocated the model rats into a placebo group (n = 40) and a PPS group (n = 40) to receive intragastric administration of normal saline and PPS, respectively. After 8 weeks of treatment, the pathological changes in the rat prostatic tissue were observed by HE staining. Results: Varied degrees of chronic inflammation and inflammatory cell infiltration were seen in the prostatic tissues of both groups of rats before the treatment. The inflammation was significantly improved after the treatment in the PPS group but not in the placebo group. Conclusion: PPS has some therapeutic effect on CNP in the rat, and its mechanism may be associated with the abilities of PPS to repair the damaged glycosaminoglycan layer and inhibit inflammation in the prostate. |
| المشرفين على المادة: | 37300-21-3 (Pentosan Sulfuric Polyester) |
| تواريخ الأحداث: | Date Created: 20110510 Date Completed: 20111115 Latest Revision: 20110506 |
| رمز التحديث: | 20231215 |
| PMID: | 21548206 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1009-3591 |
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