دورية أكاديمية
Intrahepatic response markers in chronic hepatitis B patients treated with peginterferon alpha-2a and adefovir.
| العنوان: | Intrahepatic response markers in chronic hepatitis B patients treated with peginterferon alpha-2a and adefovir. |
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| المؤلفون: | Takkenberg B; Departments of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Terpstra V, Zaaijer H, Weegink C, Dijkgraaf M, Jansen P, Beld M, Reesink H |
| المصدر: | Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2011 Oct; Vol. 26 (10), pp. 1527-35. |
| نوع المنشور: | Clinical Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: Australia NLM ID: 8607909 Publication Model: Print Cited Medium: Internet ISSN: 1440-1746 (Electronic) Linking ISSN: 08159319 NLM ISO Abbreviation: J Gastroenterol Hepatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Melbourne ; Boston : Blackwell Scientific Publications, c1986- |
| مواضيع طبية MeSH: | Adenine/*analogs & derivatives , Antiviral Agents/*therapeutic use , DNA, Circular/*analysis , DNA, Viral/*analysis , Hepatitis B virus/*drug effects , Hepatitis B, Chronic/*drug therapy , Interferon-alpha/*therapeutic use , Liver/*drug effects , Organophosphonates/*therapeutic use , Polyethylene Glycols/*therapeutic use, Adenine/therapeutic use ; Adult ; Biomarkers/analysis ; Biopsy ; Chi-Square Distribution ; Drug Therapy, Combination ; Female ; Hepatitis B Core Antigens/analysis ; Hepatitis B Surface Antigens/analysis ; Hepatitis B e Antigens/analysis ; Hepatitis B virus/genetics ; Hepatitis B virus/immunology ; Hepatitis B, Chronic/diagnosis ; Hepatitis B, Chronic/virology ; Humans ; Immunohistochemistry ; Liver/pathology ; Liver/virology ; Male ; Middle Aged ; Netherlands ; Polymerase Chain Reaction ; Predictive Value of Tests ; Recombinant Proteins/therapeutic use ; Time Factors ; Treatment Outcome ; Viral Load |
| مستخلص: | Background and Aim: We investigated whether intrahepatic markers could predict response in chronic hepatitis B virus (HBV) patients treated with peg-interferon and adefovir for 48 weeks. Methods: Intrahepatic covalently closed circular DNA (cccDNA), total intrahepatic HBV DNA and the proportion of hepatitis B surface antigen (HBsAg) and hepatitis B core antigen (HBcAg) positive hepatocytes in 16 hepatitis B e antigen (HBeAg) positive and 24 HBeAg negative patients were measured at baseline and at end of treatment. Results: Baseline intrahepatic markers were not associated with sustained virological response (SVR) defined as HBV DNA < 2000 IU/mL and persistent normal alanine aminotransferase levels at the end of follow-up (week 72). At end of treatment, intrahepatic cccDNA and total intrahepatic HBV DNA in HBeAg positive patients were significantly lower in patients with HBeAg seroconversion (P = 0.016 and P = 0.010) with positive predictive values (PPV) for SVR of 80% and 80%, respectively. In HBeAg negative patients, intrahepatic cccDNA and total intrahepatic HBV DNA had declined significantly at end of treatment (P = 0.035 and P = 0.041) and corresponding PPV for SVR was 73% and 82%. In HBeAg positive patients, median proportion of HBcAg positive hepatocytes declined significantly (P = 0.002) at end of treatment. In HBeAg negative patients, the proportion of HBsAg positive hepatocytes had declined significantly at end of treatment (P = 0.0009). Using HBsAg ≤ 7.5% as a limit, PPV for SVR in HBeAg negative patients was 83%. Conclusions: At end of treatment in HBeAg positive patients, intrahepatic cccDNA and total intrahepatic HBV DNA were predictive for SVR. In HBeAg negative patients a proportion of < 7.5% HBsAg positive hepatocytes at end of treatment was a strong predictor for SVR. (© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.) |
| سلسلة جزيئية: | ISRCTN ISRCTN77073364 |
| المشرفين على المادة: | 0 (Antiviral Agents) 0 (Biomarkers) 0 (DNA, Circular) 0 (DNA, Viral) 0 (Hepatitis B Core Antigens) 0 (Hepatitis B Surface Antigens) 0 (Hepatitis B e Antigens) 0 (Interferon-alpha) 0 (Organophosphonates) 0 (Recombinant Proteins) 3WJQ0SDW1A (Polyethylene Glycols) 6GQP90I798 (adefovir) JAC85A2161 (Adenine) Q46947FE7K (peginterferon alfa-2a) |
| تواريخ الأحداث: | Date Created: 20110512 Date Completed: 20120123 Latest Revision: 20181201 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/j.1440-1746.2011.06766.x |
| PMID: | 21557773 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1440-1746 |
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| DOI: | 10.1111/j.1440-1746.2011.06766.x |