دورية أكاديمية
Recurrent wheeze in children with Down syndrome: is it asthma?
| العنوان: | Recurrent wheeze in children with Down syndrome: is it asthma? |
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| المؤلفون: | Weijerman ME; Department of Paediatrics, VU University Medical Centre, Amsterdam, the Netherlands. m.weijerman@rijnland.nl, Brand PL, van Furth MA, Broers CJ, Gemke RJ |
| المصدر: | Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2011 Nov; Vol. 100 (11), pp. e194-7. Date of Electronic Publication: 2011 Jun 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: Norway NLM ID: 9205968 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1651-2227 (Electronic) Linking ISSN: 08035253 NLM ISO Abbreviation: Acta Paediatr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2007- : Oslo : Wiley-Blackwell Original Publication: Oslo : Scandinavian University Press, c1992- |
| مواضيع طبية MeSH: | Asthma/*diagnosis , Down Syndrome/*complications , Respiratory Sounds/*etiology, Adolescent ; Asthma/epidemiology ; Case-Control Studies ; Child ; Child, Preschool ; Comorbidity ; Down Syndrome/epidemiology ; Down Syndrome/physiopathology ; Female ; Humans ; Hypersensitivity/epidemiology ; Infant ; Infant, Newborn ; Male ; Netherlands ; Prevalence ; Respiratory Sounds/diagnosis ; Respiratory Sounds/physiopathology ; Rhinitis/epidemiology ; Risk Factors ; Siblings |
| مستخلص: | Aim: To compare the prevalence of current wheeze in children with Down syndrome (DS), their siblings, and nonrelated population controls. Methods: This was a case-control study in which the International Study of Asthma and Allergy in Childhood questionnaire for respiratory symptoms was completed by parents for 130 children with DS, 167 of their siblings, and for 119 age- and sex-matched control subjects from the general population. Results: Both wheeze ever and wheeze during the last 12 months was more commonly reported in DS than in their siblings or controls. The relative risk (RR) of current wheeze in DS was 2.8 (95% CI, 1.42-5.51) compared with siblings, and 2.75 (95% CI, 1.28-5.88) compared with controls. A doctor's diagnosis of asthma was found in 3.1% in children with DS, in 4.2% in siblings and in 6.7% in controls. During 4-years follow-up, the diagnosis of asthma could not be confirmed in the 24 DS children with current wheeze, and atopy was found in none of them. Conclusion: Wheeze is common in children with DS. This is likely to be related to the factors specific for DS and probably unrelated to asthma. (© 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.) |
| تواريخ الأحداث: | Date Created: 20110602 Date Completed: 20120213 Latest Revision: 20111011 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/j.1651-2227.2011.02367.x |
| PMID: | 21627689 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1651-2227 |
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| DOI: | 10.1111/j.1651-2227.2011.02367.x |