Quantitative estimates of the variability of in vivo sonographic measurements of the mouse aorta for studies of abdominal aortic aneurysms and related arterial diseases.

التفاصيل البيبلوغرافية
العنوان:	Quantitative estimates of the variability of in vivo sonographic measurements of the mouse aorta for studies of abdominal aortic aneurysms and related arterial diseases.
المؤلفون:	Sampson UK; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. uchechukwu.sampson@vanderbilt.edu, Perati PR, Prins PA, Pham W, Liu Z, Harrell FE Jr, Linton MF, Gore JC, Kon V, Fazio S
المصدر:	Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine [J Ultrasound Med] 2011 Jun; Vol. 30 (6), pp. 773-84.
نوع المنشور:	Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: John Wiley and Sons Country of Publication: England NLM ID: 8211547 Publication Model: Print Cited Medium: Internet ISSN: 1550-9613 (Electronic) Linking ISSN: 02784297 NLM ISO Abbreviation: J Ultrasound Med Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2017- : Oxford, UK : John Wiley and Sons Original Publication: [Philadelphia, Pa.] : W.B. Saunders, c1982-
مواضيع طبية MeSH:	Aorta/diagnostic imaging , Aortic Aneurysm, Abdominal/diagnostic imaging , Arterial Occlusive Diseases/diagnostic imaging , Echocardiography/methods, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Reproducibility of Results ; Sensitivity and Specificity
مستخلص:	Objectives: Burgeoning interest in reducing the morbidity and mortality associated with abdominal aortic aneurysms (AAAs) has led to experimental strategies to elucidate the disease process and attain pharmacologic regression using the apolipoprotein E(-/-) (ApoE(-/-)) mouse model of angiotensin-induced AAAs and in vivo sonography. However, the variability of in vivo sonographic measurements of the mouse aorta has not been established. Thus, our purpose was to determine quantitative estimates of the variability of in vivo sonographic measurements of the mouse aorta as a guide for the design and assessment of studies focused on regression of AAAs and related arterial diseases. Methods: We used Bland-Altman, locally weighted scatterplot-smoothing regression, and resampling (bootstrapping) methods for variability analyses of multiple in vivo short- and long-axis sonographic measurements of ApoE(-/-) mouse aortas. We measured distinct aortic sites in vivo at the baseline and after angiotensin-induced AAAs and ex vivo using digital calipers. Results: We analyzed 236 data points from 10 male mice (14 weeks old; mean weight ± SD, 29.7 ± 1.6 g). Overall intramouse differences between short- and long-axis and in vivo and ex vivo measurements were 0.038 (95% confidence interval [CI], 0.031-0.046) and 0.085 (95% CI, 0.062-0.109) mm, respectively. Intermouse differences in short-axis measurements were 0.047 (95% CI, 0.042-0.053), 0.049 (95% CI, 0.044-0.055), and 0.039 (95% CI, 0.036-0.042) mm for infrarenal, suprarenal, and thoracic measurements, respectively; differences in long-axis measurements were 0.054 (95% CI, 0.044-0.064), 0.029 (95% CI, 0.024-0.034), and 0.046 (95% CI, 0.037-0.054) mm. Bland-Altman and locally weighted scatterplot-smoothing analyses showed excellent agreement between measures with no variation in discrepancies vis-à-vis the target measurement. Conclusions: These data establish previously undefined estimates of measurement variability relevant for in vivo sonographic studies of AAA regression in a commonly studied mouse model.
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معلومات مُعتمدة:	R01 HL053989 United States HL NHLBI NIH HHS; HL53989 United States HL NHLBI NIH HHS; R01 HL096088 United States HL NHLBI NIH HHS; R01 HL087061 United States HL NHLBI NIH HHS; HL65709 United States HL NHLBI NIH HHS; R01 HL057986 United States HL NHLBI NIH HHS; R01 HL065709 United States HL NHLBI NIH HHS; HL57986 United States HL NHLBI NIH HHS
تواريخ الأحداث:	Date Created: 20110603 Date Completed: 20120302 Latest Revision: 20211020
رمز التحديث:	20221213
مُعرف محوري في PubMed:	PMC3810347
DOI:	10.7863/jum.2011.30.6.773
PMID:	21632991
قاعدة البيانات:	MEDLINE

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تدمد:	1550-9613
DOI:	10.7863/jum.2011.30.6.773