دورية أكاديمية
Peripheral 5-HT1B and 5-HT2A receptors mediate the nociceptive response induced by 5-hydroxytryptamine in mice.
| العنوان: | Peripheral 5-HT1B and 5-HT2A receptors mediate the nociceptive response induced by 5-hydroxytryptamine in mice. |
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| المؤلفون: | Nascimento EB Jr; Laboratório de Farmacologia, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil., Seniuk JG, Godin AM, Ferreira WC, Dutra MB, Oliveira AC, Bastos LF, Fiebich BL, Coelho MM |
| المصدر: | Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2011 Oct; Vol. 99 (4), pp. 598-603. Date of Electronic Publication: 2011 Jun 16. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0367050 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5177 (Electronic) Linking ISSN: 00913057 NLM ISO Abbreviation: Pharmacol Biochem Behav Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tarrytown, NY : Elsevier Original Publication: Phoenix, N. Y. Ankho International, ltd. |
| مواضيع طبية MeSH: | Nociceptors/*drug effects , Pain/*psychology , Receptor, Serotonin, 5-HT1B/*drug effects , Receptor, Serotonin, 5-HT2A/*drug effects , Serotonin/*pharmacology, Animals ; Behavior, Animal/drug effects ; Dose-Response Relationship, Drug ; Male ; Mice ; Receptors, Serotonin/drug effects ; Serotonin Antagonists/pharmacology |
| مستخلص: | While the role of 5-hydroxytryptamine (5-HT, serotonin) in the nociceptive processing has been widely investigated in the central nervous system, information regarding its role in peripheral tissues is still lacking. Noteworthy, 5-HT induces phenotypic changes of nociceptors and peripheral injection induces pain in humans and nociceptive response in rodents. However, local receptors involved in 5-HT effects are not well characterized. Thus, we aimed to investigate the role of 5-HT and some of its receptors in the peripheral nociceptive processing in mice. Intraplantar injection of 5-HT (10, 20 or 40 μg) into the hind-paw of mice induced paw licking behavior, which was inhibited by previous intraplantar treatment with cyproheptadine (5-HT(1) and 5-HT(2) antagonist; 0.5 or 5 μg), mianserin (5-HT(2) and 5-HT(6) antagonist; 0.1 μg), isamoltane (5-HT(1B) antagonist; 0.5 or 5 μg) and ketanserin (5-HT(2A) antagonist; 0.1 or 1 μg), but not by BRL 15572 (5-HT(1D) antagonist; 1 or 10 μg), ondansetron (5-HT(3) antagonist; 1, 5, 10 or 20 μg) and SB 269970 (5-HT(7) antagonist; 2.5 and 25 μg). Altogether, these results indicate the local involvement of 5-HT(1), 5-HT(2) and 5-HT(6), especially 5-HT(1B) and 5-HT(2A), in the nociceptive response induced by 5-HT in mice, thus contributing to a better understanding of 5-HT role in the peripheral nociceptive processing. In addition, they also point to important species differences and the need of a wide evaluation of the peripheral nociceptive processing in mice as these animals have been increasingly used in studies investigating the cellular and molecular mechanisms mediating the nociceptive response. (Copyright © 2011 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (Receptor, Serotonin, 5-HT1B) 0 (Receptor, Serotonin, 5-HT2A) 0 (Receptors, Serotonin) 0 (Serotonin Antagonists) 0 (serotonin 7 receptor) 333DO1RDJY (Serotonin) |
| تواريخ الأحداث: | Date Created: 20110625 Date Completed: 20111209 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.pbb.2011.06.016 |
| PMID: | 21699915 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-5177 |
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| DOI: | 10.1016/j.pbb.2011.06.016 |