دورية أكاديمية
أعرض في EDS

Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b.

التفاصيل البيبلوغرافية
العنوان: Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b.
المؤلفون: Rossi RL; Istituto Nazionale Genetica Molecolare, Milano, Italy., Rossetti G, Wenandy L, Curti S, Ripamonti A, Bonnal RJ, Birolo RS, Moro M, Crosti MC, Gruarin P, Maglie S, Marabita F, Mascheroni D, Parente V, Comelli M, Trabucchi E, De Francesco R, Geginat J, Abrignani S, Pagani M
المصدر: Nature immunology [Nat Immunol] 2011 Jun 26; Vol. 12 (8), pp. 796-803. Date of Electronic Publication: 2011 Jun 26.
نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Nature America Inc. c2000-
مواضيع طبية MeSH: CD4-Positive T-Lymphocytes/*immunology , MicroRNAs/*immunology , T-Lymphocyte Subsets/*immunology, Animals ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Computational Biology/methods ; Flow Cytometry ; Gene Expression Profiling/methods ; Gene Expression Regulation ; Humans ; Mice ; MicroRNAs/genetics ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Reverse Transcriptase Polymerase Chain Reaction
مستخلص: MicroRNAs are small noncoding RNAs that regulate gene expression post-transcriptionally. Here we applied microRNA profiling to 17 human lymphocyte subsets to identify microRNA signatures that were distinct among various subsets and different from those of mouse lymphocytes. One of the signature microRNAs of naive CD4+ T cells, miR-125b, regulated the expression of genes encoding molecules involved in T cell differentiation, including IFNG, IL2RB, IL10RA and PRDM1. The expression of synthetic miR-125b and lentiviral vectors encoding the precursor to miR-125b in naive lymphocytes inhibited differentiation to effector cells. Our data provide an 'atlas' of microRNA expression in human lymphocytes, define subset-specific signatures and their target genes and indicate that the naive state of T cells is enforced by microRNA.
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سلسلة جزيئية: GEO GSE22880
المشرفين على المادة: 0 (MicroRNAs)
0 (RNA, Messenger)
تواريخ الأحداث: Date Created: 20110628 Date Completed: 20111007 Latest Revision: 20211020
رمز التحديث: 20240628
DOI: 10.1038/ni.2057
PMID: 21706005
قاعدة البيانات: MEDLINE
الوصف
تدمد:1529-2916
DOI:10.1038/ni.2057