دورية أكاديمية
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Interobserver agreement for Polyomavirus nephropathy grading in renal allografts using the working proposal from the 10th Banff Conference on Allograft Pathology.

التفاصيل البيبلوغرافية
العنوان: Interobserver agreement for Polyomavirus nephropathy grading in renal allografts using the working proposal from the 10th Banff Conference on Allograft Pathology.
المؤلفون: Sar A; Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, T2V 1P9 Alberta, Canada., Worawichawong S, Benediktsson H, Zhang J, Yilmaz S, Trpkov K
المصدر: Human pathology [Hum Pathol] 2011 Dec; Vol. 42 (12), pp. 2018-24. Date of Electronic Publication: 2011 Jul 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: W B Saunders Country of Publication: United States NLM ID: 9421547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8392 (Electronic) Linking ISSN: 00468177 NLM ISO Abbreviation: Hum Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: Philadelphia, PA : W B Saunders
Original Publication: Philadelphia, W B. Saunders Co.
مواضيع طبية MeSH: Graft Rejection/*pathology , Kidney Diseases/*pathology , Kidney Transplantation/*pathology , Polyomavirus/*physiology , Polyomavirus Infections/*pathology , Tumor Virus Infections/*pathology, Adolescent ; Adult ; Aged ; Biopsy ; Child ; Female ; Graft Rejection/classification ; Graft Rejection/drug therapy ; Graft Rejection/virology ; Humans ; Kidney/pathology ; Kidney/virology ; Kidney Diseases/classification ; Kidney Diseases/drug therapy ; Kidney Diseases/virology ; Male ; Middle Aged ; Observer Variation ; Polyomavirus Infections/classification ; Polyomavirus Infections/drug therapy ; Reproducibility of Results ; Retrospective Studies ; Transplantation, Homologous/pathology ; Tumor Virus Infections/classification ; Tumor Virus Infections/drug therapy ; Viral Load ; Virus Replication
مستخلص: A classification schema for grading Polyomavirus nephropathy was proposed at the 2009 Banff allograft meeting. The schema included 3 stages of Polyomavirus nephropathy: early (stage A), florid (stage B), and late sclerosing (stage C). Grading categories for histologic viral load levels were also proposed. To examine the applicability and the interobserver agreement of the proposed Polyomavirus nephropathy grading schema, we evaluated 24 renal allograft biopsies with confirmed Polyomavirus nephropathy by histology and SV40. Four renal pathologists independently scored the Polyomavirus nephropathy stage (A, B, or C), without knowledge of the clinical history. Viral load was scored as a percent of tubules exhibiting viral replication, using either a 3-tier viral load score (1: ≤1%; 2: >1%-10%; 3: >10%) or a 4-tier score (1: ≤1%; 2: >1%-≤5%; 3: >5%-15%; 4: >15%). The κ score for the Polyomavirus nephropathy stage was 0.47 (95% confidence interval, 0.35-0.60; P < .001). There was a substantial agreement using both the 3-tier and the 4-tier scoring for the viral load (Kendall concordance coefficients, 0.72 and 0.76, respectively; P < .001 for both). A better complete agreement was found using the 3-tier viral load score. In this first attempt to evaluate the interobserver reproducibility of the proposed Polyomavirus nephropathy classifying schema, we demonstrated moderate κ agreement in assessing the Polyomavirus nephropathy stage and a substantial agreement in scoring the viral load level. The proposed grading schema can be applied in routine allograft biopsy practice for grading the Polyomavirus nephropathy stage and the viral load level.
(Copyright © 2011 Elsevier Inc. All rights reserved.)
تواريخ الأحداث: Date Created: 20110708 Date Completed: 20120109 Latest Revision: 20111114
رمز التحديث: 20240628
DOI: 10.1016/j.humpath.2011.03.008
PMID: 21733554
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-8392
DOI:10.1016/j.humpath.2011.03.008