دورية أكاديمية
أعرض في EDS

GenExp: an interactive web-based genomic DAS client with client-side data rendering.

التفاصيل البيبلوغرافية
العنوان: GenExp: an interactive web-based genomic DAS client with client-side data rendering.
المؤلفون: Gel Moreno B; Software Department, UPC-BarcelonaTech, Barcelona, Spain. bgel@lsi.upc.edu, Messeguer Peypoch X
المصدر: PloS one [PLoS One] 2011; Vol. 6 (7), pp. e21270. Date of Electronic Publication: 2011 Jul 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Internet* , Software*, Computational Biology/*methods , Genomics/*methods, Databases, Genetic ; Information Storage and Retrieval/methods ; Reproducibility of Results ; User-Computer Interface
مستخلص: Background: The Distributed Annotation System (DAS) offers a standard protocol for sharing and integrating annotations on biological sequences. There are more than 1000 DAS sources available and the number is steadily increasing. Clients are an essential part of the DAS system and integrate data from several independent sources in order to create a useful representation to the user. While web-based DAS clients exist, most of them do not have direct interaction capabilities such as dragging and zooming with the mouse.
Results: Here we present GenExp, a web based and fully interactive visual DAS client. GenExp is a genome oriented DAS client capable of creating informative representations of genomic data zooming out from base level to complete chromosomes. It proposes a novel approach to genomic data rendering and uses the latest HTML5 web technologies to create the data representation inside the client browser. Thanks to client-side rendering most position changes do not need a network request to the server and so responses to zooming and panning are almost immediate. In GenExp it is possible to explore the genome intuitively moving it with the mouse just like geographical map applications. Additionally, in GenExp it is possible to have more than one data viewer at the same time and to save the current state of the application to revisit it later on.
Conclusions: GenExp is a new interactive web-based client for DAS and addresses some of the short-comings of the existing clients. It uses client-side data rendering techniques resulting in easier genome browsing and exploration. GenExp is open source under the GPL license and it is freely available at http://gralggen.lsi.upc.edu/recerca/genexp.
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تواريخ الأحداث: Date Created: 20110714 Date Completed: 20111227 Latest Revision: 20211020
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3130039
DOI: 10.1371/journal.pone.0021270
PMID: 21750706
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0021270