Frequency of the anti-glutamic acid decarboxylase immunological marker in patients with diabetes duration longer than three years in southern Brazil.

التفاصيل البيبلوغرافية
العنوان:	Frequency of the anti-glutamic acid decarboxylase immunological marker in patients with diabetes duration longer than three years in southern Brazil.
المؤلفون:	Moreira MC; Universidade Feevale, Novo Hamburgo, Rio Grande do Sul, Brazil., Lara GM, Linden R, Feksa LR, Tavares RG, Almeida SE, Berlese DB
المصدر:	Sao Paulo medical journal = Revista paulista de medicina [Sao Paulo Med J] 2011 May; Vol. 129 (3), pp. 130-3.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Associação Paulista de Medicina Country of Publication: Brazil NLM ID: 100897261 Publication Model: Print Cited Medium: Internet ISSN: 1806-9460 (Electronic) Linking ISSN: 15163180 NLM ISO Abbreviation: Sao Paulo Med J Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: São Paulo, S.P., Brazil : Associação Paulista de Medicina, [1994-
مواضيع طبية MeSH:	Autoantibodies/blood , Diabetes Mellitus, Type 1/immunology , Glutamate Decarboxylase/*immunology, Adult ; Biomarkers/blood ; Blood Glucose/analysis ; Brazil ; Case-Control Studies ; Cross-Sectional Studies ; Fasting/blood ; Female ; Glycated Hemoglobin/analysis ; Humans ; Male ; Time Factors
مستخلص:	Context and Objective: The anti-GAD (glutamic acid decarboxylase) antibody is considered to be an important marker for type 1 diabetes mellitus (DM1), with frequency that varies depending on the population studied and the duration of the disease. Therefore, the aim of this study was to determine the frequency of this autoantibody in a group of patients in southern Brazil with DM1 that had been diagnosed more than three years previously. Design and Setting: Analytical cross-sectional study with a control group conducted at the Biomedicine Laboratory of Universidade Feevale. Methods: This study was conducted between June 2007 and December 2008, and 109 individuals were enrolled during this period. Fifty-eight were DM1 patients and 51 were individuals free from DM1 and without any history of diabetes, who constituted the control group. Results: In the DM1 group, the mean age was 27 ± 1.7 years and 50% were men. The mean fasting blood glucose in the DM1 group was 208 ± 15 mg/dl and mean HbA1c (glycosylated hemoglobin) was 8.7 ± 0.25%. In the control group, the mean fasting blood glucose and HbA1c were 82 mg/dl and 5.0% respectively. Thirty-seven individuals with DM1 (63.8%) were positive for anti-GAD, and this proportion was significantly larger than in the control group. Conclusions: These results show the high prevalence of anti-GAD in the population of diabetic patients in southern Brazil, thus indicating that the antibody was still present a long time after the disease had been diagnosed.
References:	Diabetes Care. 2003 Feb;26(2):452-7. (PMID: 12547879) Arq Bras Endocrinol Metabol. 2009 Feb;53(1):64-71. (PMID: 19347187) Diabetes Care. 2007 Jan;30 Suppl 1:S42-7. (PMID: 17192378) Diabetes. 2002 Jun;51(6):1754-62. (PMID: 12031962) Braz J Med Biol Res. 2004 Nov;37(11):1645-50. (PMID: 15517079) Arq Bras Endocrinol Metabol. 2008 Mar;52(2):166-80. (PMID: 18438527) J Clin Endocrinol Metab. 1999 Feb;84(2):643-8. (PMID: 10022431) Ann N Y Acad Sci. 2002 Apr;958:117-30. (PMID: 12021091) Rev Lat Am Enfermagem. 2005 Sep-Oct;13(5):743-9. (PMID: 16308633) Nature. 1990 Sep 13;347(6289):151-6. (PMID: 1697648) Lancet. 2006 Mar 11;367(9513):847-58. (PMID: 16530579) Rev Saude Publica. 2004 Aug;38(4):529-36. (PMID: 15311293)
المشرفين على المادة:	0 (Autoantibodies) 0 (Biomarkers) 0 (Blood Glucose) 0 (Glycated Hemoglobin A) EC 4.1.1.15 (Glutamate Decarboxylase)
تواريخ الأحداث:	Date Created: 20110715 Date Completed: 20120203 Latest Revision: 20240216
رمز التحديث:	20240216
مُعرف محوري في PubMed:	PMC10866313
DOI:	10.1590/s1516-31802011000300002
PMID:	21755246
قاعدة البيانات:	MEDLINE

Full Text Finder

الوصف
تدمد:	1806-9460
DOI:	10.1590/s1516-31802011000300002