دورية أكاديمية
Comparison of Gd-DTPA and Gd-BOPTA for studying renal perfusion and filtration.
| العنوان: | Comparison of Gd-DTPA and Gd-BOPTA for studying renal perfusion and filtration. |
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| المؤلفون: | Notohamiprodjo M; Department of Clinical Radiology, University Hospitals Munich, Munich, Germany. mike.notohamiprodjo@med.uni-muenchen.de, Pedersen M, Glaser C, Helck AD, Lodemann KP, Jespersen B, Fischereder M, Reiser MF, Sourbron SP |
| المصدر: | Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2011 Sep; Vol. 34 (3), pp. 595-607. Date of Electronic Publication: 2011 Jul 14. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 9105850 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-2586 (Electronic) Linking ISSN: 10531807 NLM ISO Abbreviation: J Magn Reson Imaging Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005-> : Hoboken , N.J. : Wiley-Liss Original Publication: Chicago, IL : Society for Magnetic Resonance Imaging, c1991- |
| مواضيع طبية MeSH: | Gadolinium DTPA* , Organometallic Compounds*, Glomerular Filtration Rate/*physiology , Image Enhancement/*methods , Image Interpretation, Computer-Assisted/*methods , Magnetic Resonance Angiography/*methods , Meglumine/*analogs & derivatives , Renal Circulation/*physiology, Animals ; Blood Flow Velocity ; Contrast Media ; Reproducibility of Results ; Sensitivity and Specificity ; Swine |
| مستخلص: | Purpose: To measure the systematic error in perfusion and filtration parameters derived from magnetic resonance (MR) renography caused by protein binding of MR contrast agents. Materials and Methods: Eight healthy Danish Landrace pigs were examined with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). In four pigs a bolus of gadopentetate-dimeglumine (Gd-DTPA; no protein binding) was injected, followed by gadobenate-dimeglumine (Gd-BOPTA; 10% protein binding). The order was reversed in the other four pigs. A two-compartment filtration model was generalized to allow for protein binding and fitted to whole-cortex region of interest (ROI) curves. Single-kidney plasma flow and volume, tubular flow (or GFR), and tubular transit time of both agents were compared. Results: The data show a strong systematic underestimation (P < 0.001) in GFR by Gd-BOPTA (33 ± 7.2%), and no significant differences (P > 0.05) in plasma flow (2.2 ± 18%), plasma volume (-1.7 ± 7.8%) and tubular transit time (3.1 ± 7.2%). The order of injection had no significant effect. Conclusion: Theory and experiments agree that perfusion parameters of both agents are comparable, whereas GFR is underestimated with Gd-BOPTA due to the dependence of relaxivity on protein content. Hence, GFR cannot be measured with protein-bound contrast agents, but the proposed dual-agent protocol may produce new functional indices measuring protein filtration. (Copyright © 2011 Wiley-Liss, Inc.) |
| المشرفين على المادة: | 0 (Contrast Media) 0 (Organometallic Compounds) 15G12L5X8K (gadobenic acid) 6HG8UB2MUY (Meglumine) K2I13DR72L (Gadolinium DTPA) |
| تواريخ الأحداث: | Date Created: 20110716 Date Completed: 20121113 Latest Revision: 20151119 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/jmri.22640 |
| PMID: | 21761461 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1522-2586 |
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| DOI: | 10.1002/jmri.22640 |