دورية أكاديمية
Prevalence, genotypes and factors associated with HCV infection among prisoners in Northeastern Brazil.
| العنوان: | Prevalence, genotypes and factors associated with HCV infection among prisoners in Northeastern Brazil. |
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| المؤلفون: | Santos BF; Department of Medicine, Federal University of Sergipe, Aracaju, Sergipe 49060-100, Brazil., de Santana NO, Franca AV |
| المصدر: | World journal of gastroenterology [World J Gastroenterol] 2011 Jul 07; Vol. 17 (25), pp. 3027-34. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing : WJG Press, c1998- |
| مواضيع طبية MeSH: | Genotype* , Prisoners*, Hepacivirus/*genetics , Hepatitis C/*epidemiology, Adult ; Brazil/epidemiology ; Cross-Sectional Studies ; Female ; Hepatitis C/genetics ; Hepatitis C/transmission ; Humans ; Male ; ROC Curve ; Seroepidemiologic Studies ; Young Adult |
| مستخلص: | Aim: To determine hepatitis C virus (HCV) seroprevalence and its genotypes, and to identify the factors associated with HCV infection. Methods: This cross-sectional study, conducted in two prisons (one male and one female) in the State of Sergipe, Brazil, comprised 422 subjects. All of the prisoners underwent a rapid test for the detection of HCV antibodies. Patients with a positive result were tested for anti-HCV by enzyme linked immunosorbent assay and for HCV RNA by qualitative polymerase chain reaction (PCR). The virus genotype was defined in every serum sample that presented positive for PCR-HCV. In order to determine the factors independently associated with positive serology for HCV, multivariate logistic regression was used. Results: HCV seroprevalence was 3.1%. Of the 13 subjects with positive anti-HCV, 11 had viremia confirmed by PCR. Of these, 90.9% had genotype 1. A total of 43 (10.2%) were injecting drug users, and HCV seroprevalence in this subgroup was 20.6%. The variable most strongly associated with positive serology for HCV was use of injecting drugs [odds ratio (OR), 23.3; 95% confidence interval (CI), 6.0-90.8]. Age over 30 years (OR, 5.5; 95%CI, 1.1-29.2), history of syphilis (OR, 9.8; 95%CI, 1.7-55.2) and history of household contact with HCV positive individual (OR, 14.1; 95%CI, 2.3-85.4) were also independently associated with HCV infection. Conclusion: Most of the HCV transmissions result from parenteral exposure. However, there is evidence to suggest a role for sex and household contact with an infected subject in virus transmission. |
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| فهرسة مساهمة: | Keywords: Brazil; Cross sectional analysis; Drug abusers; Hepatitis C; Prisoners |
| تواريخ الأحداث: | Date Created: 20110730 Date Completed: 20111031 Latest Revision: 20211020 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC3132254 |
| DOI: | 10.3748/wjg.v17.i25.3027 |
| PMID: | 21799649 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2219-2840 |
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| DOI: | 10.3748/wjg.v17.i25.3027 |