دورية أكاديمية
Frontal subcortical ischemia is crucial for post stroke cognitive impairment.
| العنوان: | Frontal subcortical ischemia is crucial for post stroke cognitive impairment. |
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| المؤلفون: | Kandiah N; Department of Neurology, National Neuroscience Institute, Singapore. Nagaendran_Kandiah@nni.com.sg, Wiryasaputra L, Narasimhalu K, Karandikar A, Marmin M, Chua EV, Sitoh YY |
| المصدر: | Journal of the neurological sciences [J Neurol Sci] 2011 Oct 15; Vol. 309 (1-2), pp. 92-5. Date of Electronic Publication: 2011 Jul 31. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375403 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5883 (Electronic) Linking ISSN: 0022510X NLM ISO Abbreviation: J Neurol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, <19 -> |
| مواضيع طبية MeSH: | Brain Ischemia/*diagnosis , Brain Ischemia/*epidemiology , Cognition Disorders/*diagnosis , Cognition Disorders/*epidemiology , Stroke, Lacunar/*diagnosis , Stroke, Lacunar/*epidemiology, Adult ; Aged ; Brain Ischemia/psychology ; Cognition Disorders/psychology ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/psychology ; Stroke, Lacunar/psychology |
| مستخلص: | Background: The incidence of post stroke cognitive impairment (PSCI) and predictive factors for PSCI among patients with acute lacunar infarcts is unclear. Objective: To study the impact of acute lacunar infarcts and chronic white matter disease in the development of PSCI. Methods: Prospective cohort study of stroke patients attending a tertiary neurology center. Patients with MRI confirmed acute lacunar infarcts without pre-existing dementia were recruited. Logistic regression was used to determine risk factors for developing PSCI. Results: 145 patients with a mean age of 55.8 years were studied of which 48 patients (33.1%) were identified to have PSCI. Patients with PSCI performed worse on the MMSE, MOCA and FAB and had significantly greater white matter hyperintensity (WMH) in the frontal subcortical (FSC) region (p = 0.006) and higher frontal subcortical acute infarct load (p = 0.002). Logistic regression demonstrated that deep subcortical WMH (odds ratio, OR = 1.45) and acute FSC infarcts (OR = 1.51) were associated with PSCI. High WMH load without acute FSC infarcts was associated with increased risk of PSCI (OR = 4.1). When patients developed acute FSC infarcts on pre-existing severe WMH, the risk of PSCI increased substantially (OR = 11.0). Conclusions: Patients with acute lacunar infarcts in the FSC region have 1.5 times risk of PSCI. This risk increases substantially to 11 times when there is pre-existing severe white matter disease. (Copyright © 2011 Elsevier B.V. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20110803 Date Completed: 20120621 Latest Revision: 20220408 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.jns.2011.07.013 |
| PMID: | 21807379 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1878-5883 |
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| DOI: | 10.1016/j.jns.2011.07.013 |