دورية أكاديمية
Serum testosterone levels of HbSS (sickle cell disease) male subjects in Lagos, Nigeria.
| العنوان: | Serum testosterone levels of HbSS (sickle cell disease) male subjects in Lagos, Nigeria. |
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| المؤلفون: | Abudu EK; Department of Haematology and Blood Transfusion, Lagos State University, College of Medicine, Ikeja, Nigeria. ajoke_clinic@yahoo.co.uk., Akanmu SA, Soriyan OO, Akinbami AA, Adediran A, Adeyemo TA, Okany CC |
| المصدر: | BMC research notes [BMC Res Notes] 2011 Aug 17; Vol. 4, pp. 298. Date of Electronic Publication: 2011 Aug 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500 (Electronic) Linking ISSN: 17560500 NLM ISO Abbreviation: BMC Res Notes Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Biomed Central, 2008. |
| مستخلص: | Background: Infertility is a major problem in sickle cell disease patients, especially in males. In addition to low serum testosterone, other abnormalities involving the accessory sex organs, such as the seminal vesicles and the prostate gland, as well as marked decrease in ejaculate volume may be observed in male HbSS patients. Hence, the need to study the role of sex hormones as a cause of infertility in male HbSS patients. Methods: An unmatched case-control study was performed using seventy-five consenting subjects from Lagos University Teaching Hospital. These included 47 patients with haemoglobin phenotype SS from the Sickle cell clinic and 28 volunteered medical students and members of staff with haemoglobin phenotype AA. Demographic data were obtained using a self-administered questionnaire. A total of 5 mls of blood was collected from each subject between 9.00 am & 11.am, and assayed for serum testosterone concentration. Results: The concentrations of serum testosterone in HbSS patients ranged from 0.2 to 4.3 ng/ml with a mean of 1.28 ± 0.72 ng/ml whilst the values in HbAA controls ranged from 1.2 to 6.9 ng/ml with a mean of 2.63 ± 1.04 ng/ml. Seven (25.0%) of the 28 controls had serum testosterone concentration lower than the quoted reference (normal) range whereas 44 (93.6%) of the 47 HbSS subjects had serum testosterone concentration lower than the reference range. Conclusion: Overall, subjects with HbSS have significantly lower mean serum testosterone than HbAA controls. |
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| تواريخ الأحداث: | Date Created: 20110819 Date Completed: 20111110 Latest Revision: 20240320 |
| رمز التحديث: | 20240320 |
| مُعرف محوري في PubMed: | PMC3170610 |
| DOI: | 10.1186/1756-0500-4-298 |
| PMID: | 21849076 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1756-0500 |
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| DOI: | 10.1186/1756-0500-4-298 |