دورية أكاديمية
CD4+ T lymphocyte reference values of immunocompetent subjects in an African university.
| العنوان: | CD4+ T lymphocyte reference values of immunocompetent subjects in an African university. |
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| المؤلفون: | Pennap GR; Nasarawa State University, Keffi, Nasarawa State, Nigeria., Adoga MP, Forbi JC, Ojobo F, Agwale SM |
| المصدر: | Tropical doctor [Trop Doct] 2011 Oct; Vol. 41 (4), pp. 218-21. Date of Electronic Publication: 2011 Sep 13. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: England NLM ID: 1301706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1758-1133 (Electronic) Linking ISSN: 00494755 NLM ISO Abbreviation: Trop Doct Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oct. 2012- : London : Sage Original Publication: <1971>-July 2012 : London, Royal Society of Medicine |
| مواضيع طبية MeSH: | CD4 Lymphocyte Count/*standards , CD4-Positive T-Lymphocytes/*cytology , Immunocompetence/*immunology , Students/*statistics & numerical data, Adult ; CD4-Positive T-Lymphocytes/immunology ; Female ; Humans ; Male ; Nigeria ; Reference Values ; Universities |
| مستخلص: | CD4(+) T cells play critical roles in the immune system and, being primary targets of HIV infection, they are used to measure disease progression and response to combination antiretroviral therapy (cART), alongside other parameters, in HIV/AIDS patients. The aim of this study was to determine the reference values of CD4(+) T cells in a student population that was HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) negative. After ethical clearance and informed consent, 500 subjects (mean age = 26 years) were recruited, of whom 56 (11.2%) had HIV, HBV or HCV and were excluded. Blood samples were collected from the remaining 444 subjects into vacutainer tubes and analysed using the BD FACScount cytometer according to the manufacturer's instructions. Of the 444 subjects, 266 (59.9%) were male and 178 (40.1%) were female. The mean (± standard deviation) CD4(+) T cell count was 987 cells/µL (± 336). The mean counts among males and females were 957 cells/µL (± 306) and 991 cells/µL (± 340), respectively. Values of CD4(+) T cells ranged from 651 cells/µL to 1705 cells/µL. Subjects with higher CD4(+) T Cells were more likely to be female than male. There was no direct correlation between CD4(+) T cell values and age of the participants. Our findings offer the first insight into the CD4(+) T cell reference values of a Nigerian student population and provide useful data that will guide future cART decisions and other immune-based therapies. |
| تواريخ الأحداث: | Date Created: 20110915 Date Completed: 20120111 Latest Revision: 20110928 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1258/td.2011.110219 |
| PMID: | 21914674 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1758-1133 |
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| DOI: | 10.1258/td.2011.110219 |