دورية أكاديمية
Diverticulosis and colorectal polyps at younger age: a possible link?
| العنوان: | Diverticulosis and colorectal polyps at younger age: a possible link? |
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| المؤلفون: | Rondagh EJ; Department of Internal Medicine, Division of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, The Netherlands. eveline.rondagh@maastrichtuniversity.nl, Sanduleanu S, le Clercq CM, Winkens B, Masclee AA |
| المصدر: | European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2011 Nov; Vol. 23 (11), pp. 1050-5. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams And Wilkins Country of Publication: England NLM ID: 9000874 Publication Model: Print Cited Medium: Internet ISSN: 1473-5687 (Electronic) Linking ISSN: 0954691X NLM ISO Abbreviation: Eur J Gastroenterol Hepatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Lippincott Williams And Wilkins Original Publication: [London, UK ; Philadelphia, PA, USA] : Current Science, c1989- |
| مواضيع طبية MeSH: | Colonic Polyps/*etiology , Colorectal Neoplasms/*etiology , Diverticulosis, Colonic/*complications, Adenoma/etiology ; Adenoma/pathology ; Adult ; Age Factors ; Aged ; Colonic Polyps/pathology ; Colonoscopy/methods ; Colorectal Neoplasms/pathology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Risk Factors |
| مستخلص: | Objective: An association between diverticulosis and colorectal neoplasms may have implications for colonoscopic prevention of colorectal cancer. We aimed to examine the association between diverticulosis and colorectal polyps with special attention to the age at diagnosis, the anatomical location, and the histological subtype of colorectal polyps. Methods: We included all consecutive patients referred for routine colonoscopy between February 2008 and February 2009. We recorded the presence of diverticulosis (defined as at least two diverticula) and colorectal polyps (adenomas and serrated polyps). Results: We included 2310 patients (46.1% men, mean age 58.4 years), of which 37.0% had diverticulosis and 34.2% had one or more colorectal polyps. Multiple logistic regression analysis, including age, sex, and interaction terms with diverticulosis, showed that the association between diverticulosis and colorectal polyps was significantly influenced by age (P=0.009). In patients aged below 60 years, prevalence of colorectal polyps was significantly higher in those with diverticulosis compared with those without diverticulosis: 39.1% (79 of 202 patients) versus 19.6% (176 of 898 patients), adjusted odds ratio (OR) 1.87, 95% confidence interval (CI) 1.26-2.78, and P=0.002. This association was found for both proximal and distal polyps and for all histological subtypes, namely adenomas (adjusted OR 1.60, 95%CI 1.02-2.49, P=0.04), serrated polyps (adjusted OR 1.73, 95% CI 1.03-2.91, and P=0.04), and advanced neoplasms (adjusted OR 2.32, 95%CI 1.31-4.12, P=0.004). Conclusion: Presence of diverticulosis in patients aged below 60 years may be considered a 'red flag' for synchronous adenomas, serrated polyps, and advanced neoplasms. Diverticulosis may represent an indication for earlier initiation of colorectal cancer prevention programs. |
| تواريخ الأحداث: | Date Created: 20110915 Date Completed: 20120131 Latest Revision: 20220408 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1097/MEG.0b013e32834b0e44 |
| PMID: | 21915058 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-5687 |
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| DOI: | 10.1097/MEG.0b013e32834b0e44 |