دورية أكاديمية
أعرض في EDS

Non-perforating small bowel Crohn's disease assessed by MRI enterography: derivation and histopathological validation of an MR-based activity index.

التفاصيل البيبلوغرافية
العنوان: Non-perforating small bowel Crohn's disease assessed by MRI enterography: derivation and histopathological validation of an MR-based activity index.
المؤلفون: Steward MJ; Department of Specialist Imaging, University College Hospital London, 235 Euston Road, London NW1 2BU, United Kingdom. mikejsteward@gmail.com, Punwani S, Proctor I, Adjei-Gyamfi Y, Chatterjee F, Bloom S, Novelli M, Halligan S, Rodriguez-Justo M, Taylor SA
المصدر: European journal of radiology [Eur J Radiol] 2012 Sep; Vol. 81 (9), pp. 2080-8. Date of Electronic Publication: 2011 Sep 15.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Validation Study
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Ireland Ltd Country of Publication: Ireland NLM ID: 8106411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7727 (Electronic) Linking ISSN: 0720048X NLM ISO Abbreviation: Eur J Radiol Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier Science Ireland Ltd
Original Publication: Stuttgart ; New York : Thieme, [c1981-
مواضيع طبية MeSH: Algorithms* , Severity of Illness Index*, Crohn Disease/*pathology , Image Interpretation, Computer-Assisted/*methods , Intestine, Small/*pathology , Magnetic Resonance Imaging/*methods, Adolescent ; Adult ; Aged ; Female ; Humans ; Image Enhancement/methods ; Intestinal Perforation/pathology ; Intestine, Small/injuries ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity ; Young Adult
مستخلص: Objectives: To develop and validate a qualitative scoring system for enteric Crohn's disease activity using MR enterography (MRE).
Methods: MRE was performed in 16 patients (mean age 33, 8 male) undergoing small bowel resection. Mural thickness, T2 signal, contrast enhancement, and perimural oedema were scored qualitatively (0-3) at 44 locations. Transmural histopathological scoring of acute inflammation (AIS) was performed at all locations (score 0-13). MRI parameters best predicting AIS were derived using multivariate analysis. The MRI activity index was applied to 26 Crohn's patients (mean age 32, range 13-69 years, 15 male) and correlated to terminal ileal biopsy scores of acute inflammation ("eAIS" score 1-6). Receiver operator characteristic curves were calculated.
Results: Mural thickness (coefficient 1.34 (95% CI 0.36, 2.32)], p=0.007) and T2 signal (coefficient 0.90 (95% CI -0.24, 2.04) p=0.06) best predicted AIS (AIS=1.79+1.34*mural thickness+0.94*mural T2 score [R-squared 0.52]). There was a significant correlation between the MRI index and eAIS (Kendall's tau=0.40, 95% CI 0.11-0.64, p=0.02). The model achieved a sensitivity of 0.81 (95% CI 0.54-0.96), specificity of 0.70 (0.35-0.93) and AUC 0.77 for predicting acute inflammation (eAIS ≥2).
Conclusions: A simple qualitative MRI Crohn's disease activity score appears predictive against a histopathological standard of reference.
(Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)
معلومات مُعتمدة: United Kingdom Department of Health
تواريخ الأحداث: Date Created: 20110920 Date Completed: 20130114 Latest Revision: 20220409
رمز التحديث: 20221213
DOI: 10.1016/j.ejrad.2011.07.013
PMID: 21924572
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7727
DOI:10.1016/j.ejrad.2011.07.013