دورية أكاديمية
Tuberculosis in household contacts of multidrug-resistant tuberculosis patients.
| العنوان: | Tuberculosis in household contacts of multidrug-resistant tuberculosis patients. |
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| المؤلفون: | Grandjean L; The Wellcome Centre for Clinical Tropical Medicine, Imperial College, London, UK. drlouisgrandjean@hotmail.com, Crossa A, Gilman RH, Herrera C, Bonilla C, Jave O, Cabrera JL, Martin L, Escombe AR, Moore DA |
| المصدر: | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2011 Sep; Vol. 15 (9), pp. 1164-9, i. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: The Union Country of Publication: France NLM ID: 9706389 Publication Model: Print Cited Medium: Internet ISSN: 1815-7920 (Electronic) Linking ISSN: 10273719 NLM ISO Abbreviation: Int J Tuberc Lung Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Paris, France : The Union, c1997- |
| مواضيع طبية MeSH: | Family Characteristics*, Antitubercular Agents/*therapeutic use , Tuberculosis, Multidrug-Resistant/*epidemiology, Adolescent ; Adult ; Cohort Studies ; Cost of Illness ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Microbial Sensitivity Tests ; Multivariate Analysis ; Peru/epidemiology ; Proportional Hazards Models ; Retrospective Studies ; Tuberculosis, Multidrug-Resistant/drug therapy ; Young Adult |
| مستخلص: | Setting: The burden of tuberculosis (TB) disease among household contacts of multidrug-resistant TB (MDR-TB) patients is poorly understood and might represent a target for transmission-interrupting interventions. Design: This retrospective cohort study, conducted in Lima, Peru, from June to September 2008, estimated the incidence of TB disease among household contacts of MDR-TB patients in 358 households. Results: Of 2112 household contacts in 80 households (22% of households), 108 (5%) developed TB disease during the study, giving an incidence rate of 2360 per 100 000 contact follow-up years for each of the first 3 years after exposure. Drug susceptibility tests (DST) were available for 50 diseased contacts, of whom 36 (80%) had MDR-TB. Forty-two pairs of index-contact DSTs were available, among which the contact had an identical or less resistant phenotype than the index case in 27 pairs. Multivariate Cox regression demonstrated that male contacts (hazard ratio [HR] 2.8, P < 0.05), with previous TB disease (HR 20.7, P < 0.001) and with associated (non-human immunodeficiency virus) comorbidities (HR 11.2, P < 0.001) were more likely to develop TB. Conclusion: The high percentage of diseased household contacts highlights an opportunity for household-level interventions to prevent transmission, whether or not these cases were all attributable to the index case. |
| التعليقات: | Comment in: Int J Tuberc Lung Dis. 2011 Sep;15(9):1137-8. (PMID: 21943835) |
| المشرفين على المادة: | 0 (Antitubercular Agents) |
| تواريخ الأحداث: | Date Created: 20110928 Date Completed: 20120120 Latest Revision: 20220410 |
| رمز التحديث: | 20231215 |
| DOI: | 10.5588/ijtld.11.0030 |
| PMID: | 21943839 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1815-7920 |
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| DOI: | 10.5588/ijtld.11.0030 |