دورية أكاديمية
HPV and head and neck cancer.
| العنوان: | HPV and head and neck cancer. |
|---|---|
| المؤلفون: | Dufour X; Service d'ORL, de chirurgie cervico-maxillo-faciale et d'audiophonologie, CHU de Poitiers, 2 rue de La-Milétrie, Poitiers cedex, France., Beby-Defaux A, Agius G, Lacau St Guily J |
| المصدر: | European annals of otorhinolaryngology, head and neck diseases [Eur Ann Otorhinolaryngol Head Neck Dis] 2012 Feb; Vol. 129 (1), pp. 26-31. Date of Electronic Publication: 2011 Sep 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Masson SAS Country of Publication: France NLM ID: 101531465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-730X (Electronic) Linking ISSN: 18797296 NLM ISO Abbreviation: Eur Ann Otorhinolaryngol Head Neck Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Issy les Moulineaux] : Elsevier Masson SAS |
| مواضيع طبية MeSH: | Head and Neck Neoplasms/*virology , Papillomavirus Infections/*complications, Head and Neck Neoplasms/diagnosis ; Humans |
| مستخلص: | Head and neck cancer is frequent worldwide and oropharyngeal locations are presently sharply on the increase, in relation with an increasing incidence of oropharyngeal infection by oncogenic type-16 human papillomavirus (HPV). The clinical and biologic profile of these patients is distinct from that of other oropharyngeal carcinoma patients, with earlier onset, cystic cervical nodes and basaloid carcinoma histopathology. Detection of intratumoral viral DNA is essential to confirm the role of HPV, and E6/E7 mRNA expression is the most relevant indicator for stratification. Several methods can reveal intratumoral oncogenic HPV DNA, but PCR with hybridization is the most sensitive and most widely used. According to several reports, prognosis in terms of survival and locoregional control is better in HPV-positive oropharyngeal carcinoma than in oropharyngeal carcinoma associated with smoking and alcohol consumption. The future lies in vaccination, but further studies will determine whether the rate of oropharyngeal carcinoma falls in women vaccinated against cervical cancer. (Copyright © 2011 Elsevier Masson SAS. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20110928 Date Completed: 20120730 Latest Revision: 20141030 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.anorl.2011.05.004 |
| PMID: | 21944953 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-730X |
|---|---|
| DOI: | 10.1016/j.anorl.2011.05.004 |