دورية أكاديمية
Gynaecological and obstetric bleeding in moderate and severe von Willebrand disease.
| العنوان: | Gynaecological and obstetric bleeding in moderate and severe von Willebrand disease. |
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| المؤلفون: | De Wee EM; Erasmus University Medical Center, 3000 CA Rotterdam, Netherlands., Knol HM, Mauser-Bunschoten EP, van der Bom JG, Eikenboom JC, Fijnvandraat K, De Goede-Bolder A, Laros-van Gorkom B, Ypma PF, Zweegman S, Meijer K, Leebeek FW |
| مؤلفون مشاركون: | WiN study group |
| المصدر: | Thrombosis and haemostasis [Thromb Haemost] 2011 Nov; Vol. 106 (5), pp. 885-92. Date of Electronic Publication: 2011 Sep 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Thieme Country of Publication: Germany NLM ID: 7608063 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2567-689X (Electronic) Linking ISSN: 03406245 NLM ISO Abbreviation: Thromb Haemost Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : Stuttgart : Thieme Original Publication: Stuttgart, Schattauer. |
| مواضيع طبية MeSH: | Menorrhagia/*etiology , Postpartum Hemorrhage/*etiology , von Willebrand Diseases/*complications , von Willebrand Diseases/*diagnosis, Abortion, Spontaneous/etiology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Blood Coagulation Tests ; Cross-Sectional Studies ; Female ; Fetal Death/etiology ; Health Surveys ; Humans ; Hysterectomy ; Live Birth ; Menorrhagia/blood ; Menorrhagia/diagnosis ; Menorrhagia/surgery ; Middle Aged ; Netherlands ; Postpartum Hemorrhage/blood ; Postpartum Hemorrhage/diagnosis ; Postpartum Hemorrhage/surgery ; Pregnancy ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Treatment Outcome ; Young Adult ; von Willebrand Diseases/blood |
| مستخلص: | A nation-wide cross-sectional study was initiated to assess gynaecological and obstetrical symptoms in an unselected cohort of women with moderate and severe von Willebrand disease (VWD) in the Netherlands. A total of 423 women aged ≥16 years were included. Bleeding severity was measured using the Tosetto Bleeding Score (BS). Menorrhagia, defined as occurrence of ≥2 menorrhagia symptoms, was reported by 81%. Of all VWD women, 78% received any kind of treatment for menorrhagia and 20% underwent a hysterectomy predominantly because of severe menstrual bleeding. Over half of the women reported more blood loss than can be expected with a normal delivery. In 52% of reported pregnancy losses curettage was needed because of bleeding. Mean number of live births was 1.9, which is comparable with the general Dutch population. In conclusion, women with moderate or severe VWD frequently have menorrhagia in need of treatment, and 20% of the VWD women underwent a hysterectomy. Bleeding complications occurred in over 50% of the women after childbirth or pregnancy loss. Progeny seems not to be affected in women with moderate or severe VWD. |
| فهرسة مساهمة: | Investigator: K Fijnvandraat; PW Kamphuisen; A Kors; S Zweegman; ME Degenaar-Dujardin; GJ Goverde; MH Jonkers; N Dors; WJ Hofhuis; MR Nijziel; K Meijer; RY Tamminga; PW van der Linden; PF Ypma; JG van der Bom; HC Eikenboom; FJ Smiers; B Granzen; K Hamulyák; P Brons; BA Laros-van Gorkom; I Nováková; A de Goede-Bolder; FW Leebeek; EM de Wee; EP Mauser-Bunschoten |
| تواريخ الأحداث: | Date Created: 20110928 Date Completed: 20120229 Latest Revision: 20220331 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1160/TH11-03-0180 |
| PMID: | 21947221 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2567-689X |
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| DOI: | 10.1160/TH11-03-0180 |