دورية أكاديمية
Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice.
| العنوان: | Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice. |
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| المؤلفون: | Sackmann-Sala L; Edison Biotechnology Institute, Ohio University, 1 Water Tower Dr., The Ridges, Athens, OH 45701, USA., Berryman DE, Lubbers ER, Vesel CB, Troike KM, List EO, Munn RD, Ikeno Y, Kopchick JJ |
| المصدر: | Age (Dordrecht, Netherlands) [Age (Dordr)] 2012 Oct; Vol. 34 (5), pp. 1225-37. Date of Electronic Publication: 2011 Sep 29. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Netherlands NLM ID: 101250497 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1574-4647 (Electronic) Linking ISSN: 01619152 NLM ISO Abbreviation: Age (Dordr) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Dordrecht, The Netherlands ; Hingham, MA : Springer, c2005- |
| مواضيع طبية MeSH: | Oxidative Stress*, Adipose Tissue/*metabolism , Adipose Tissue, White/*metabolism , Aging/*physiology , Insulin/*metabolism , Insulin Resistance/*physiology , Obesity/*metabolism, Adipocytes/metabolism ; Adipose Tissue, White/pathology ; Animals ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/pathology ; Proteomics |
| مستخلص: | Unintentional weight loss (wasting) in the elderly is a major health concern as it leads to increased mortality. Several studies have focused on muscle loss, but little is known about the mechanisms giving rise to loss of fat mass at old ages. To investigate potential mechanisms, white adipose tissue (WAT) characteristics and proteomic profiles were compared between adult (10-12-month-old) and aged (22-24-month-old) wild-type mice. Four individual WAT depots were analyzed to account for possible depot-specific differences. Proteomic profiles of WAT depots, along with body weights and compositions, plasma levels of insulin, leptin and adiponectin, insulin tolerance, adipocyte sizes, and products of oxidative damage in each WAT depot were determined. We found that lean mass remained constant while fat mass and insulin tolerance were decreased in old age, as were adipocyte sizes in the WAT depots. Proteomic results showed increased levels of enolase, pyruvate dehydrogenase E1β, NAD(+)-dependent isocitrate dehydrogenase α, and ATP synthase subunit β, and decreased levels of carbonic anhydrase 3 in WAT of aged mice. These data suggest increased aerobic glucose oxidation in wasting WAT, consistent with decreased insulin signaling. Also, Cu/Zn superoxide dismutase and two chaperones were increased in aged WAT depots, indicating higher stress resistance. In agreement, lipid peroxidation (HNE-His adducts) increased in old age, although protein oxidation (carbonyl groups) showed no increase. In conclusion, features of wasting WAT were similar in the four depots, including decreased adipocyte sizes and alterations in protein expression profiles that indicated decreased insulin sensitivity and increased lipid peroxidation. |
| References: | Ann N Y Acad Sci. 1984;429:505-15. (PMID: 6331259) Mini Rev Med Chem. 2010 Aug;10(9):856-69. (PMID: 20482500) J Appl Physiol (1985). 2011 Jan;110(1):149-56. (PMID: 20966191) Obesity (Silver Spring). 2010 Oct;18(10):1875-80. (PMID: 20300084) Clin Proteomics. 2010 Jun 1;6(1-2):6-17. (PMID: 20625478) J Am Geriatr Soc. 2011 Jun;59(6):1003-11. (PMID: 21649624) Eur J Endocrinol. 2011 Feb;164(2):157-67. (PMID: 21059862) Free Radic Biol Med. 2007 Aug 15;43(4):477-503. (PMID: 17640558) J Lipid Res. 2002 Dec;43(12):2105-11. (PMID: 12454272) Horm Metab Res. 2002 Nov-Dec;34(11-12):616-21. (PMID: 12660870) Curr Pharm Des. 2007;13(35):3637-47. (PMID: 18220800) Cell Metab. 2008 May;7(5):410-20. (PMID: 18460332) Antioxid Redox Signal. 2010 Mar;12(3):393-404. (PMID: 19686045) Clin Med (Lond). 2011 Feb;11(1):72-5. (PMID: 21404792) Br J Cancer. 2010 May 11;102(10):1541-8. (PMID: 20407445) J Clin Endocrinol Metab. 2011 Jul;96(7):2089-97. (PMID: 21543428) Br J Pharmacol. 2004 May;142(2):231-55. (PMID: 15155533) Nat Med. 1995 Nov;1(11):1155-61. (PMID: 7584987) J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):562-7. (PMID: 16799137) Growth Horm IGF Res. 2011 Jun;21(3):113-23. (PMID: 21470887) Proteomics. 2007 Apr;7(7):1140-9. (PMID: 17390296) Cancer Res. 2007 Jun 1;67(11):5531-7. (PMID: 17545636) Postgrad Med J. 2006 Jan;82(963):2-8. (PMID: 16397072) Diabetes Care. 1981 Jul-Aug;4(4):493-501. (PMID: 7049632) Age (Dordr). 2011 Sep;33(3):291-307. (PMID: 20842533) Obesity (Silver Spring). 2012 Jan;20(1):101-11. (PMID: 21779095) Curr Opin Clin Nutr Metab Care. 2008 May;11(3):201-7. (PMID: 18403913) J Int Med Res. 2009 Nov-Dec;37(6):1803-12. (PMID: 20146878) Growth Horm IGF Res. 2009 Dec;19(6):471-7. (PMID: 19386527) Ann N Y Acad Sci. 1984;429:525-7. (PMID: 6430190) J Gerontol A Biol Sci Med Sci. 2009 Oct;64(10):1039-44. (PMID: 19587105) Br J Nutr. 1986 Jul;56(1):29-48. (PMID: 3676203) Biochem Biophys Res Commun. 2010 May 21;396(1):101-4. (PMID: 20494119) FEBS Lett. 2006 Nov 27;580(27):6391-8. (PMID: 17098232) Proteomics. 2009 Feb;9(4):989-1003. (PMID: 19180535) Am J Physiol. 1990 Feb;258(2 Pt 1):C206-10. (PMID: 2305864) Eur J Clin Invest. 2008 Nov;38(11):827-34. (PMID: 19021700) Mol Cell Proteomics. 2005 Sep;4(9):1311-8. (PMID: 15961380) Metabolism. 1998 May;47(5):535-40. (PMID: 9591743) J Gerontol A Biol Sci Med Sci. 2010 Mar;65(3):242-51. (PMID: 20106964) Cancer. 2005 May 15;103(10):2189-98. (PMID: 15822132) Nat Med. 1995 Dec;1(12):1311-4. (PMID: 7489415) Gastroenterol Clin North Am. 2009 Sep;38(3):393-409. (PMID: 19699404) J Am Geriatr Soc. 1993 Mar;41(3):211-3. (PMID: 8440839) Am J Physiol. 1984 May;246(5 Pt 1):E397-404. (PMID: 6426315) J Gerontol A Biol Sci Med Sci. 2009 May;64(5):522-9. (PMID: 19228785) Physiol Rev. 2006 Apr;86(2):651-67. (PMID: 16601270) Neurobiol Aging. 2012 Jan;33(1):206.e41-53. (PMID: 20970890) Nat Med. 2001 Aug;7(8):941-6. (PMID: 11479627) Transgenic Res. 2011 Dec;20(6):1305-20. (PMID: 21365322) Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1159-68. (PMID: 17584954) J Biol Chem. 1996 May 3;271(18):10697-703. (PMID: 8631877) J Gerontol A Biol Sci Med Sci. 2010 Nov;65(11):1208-14. (PMID: 20616148) Proteomics. 2009 Dec;9(24):5509-24. (PMID: 19834913) Int J Cardiol. 2012 Feb 23;155(1):56-65. (PMID: 21345498) Science. 2011 Jul 8;333(6039):233-8. (PMID: 21680814) N Engl J Med. 1996 Feb 1;334(5):292-5. (PMID: 8532024) J Proteomics. 2011 May 1;74(5):716-27. (PMID: 21354350) J Proteomics. 2010 Jun 16;73(8):1441-53. (PMID: 20153846) J Nutr Health Aging. 2008 Aug-Sep;12(7):487-91. (PMID: 18615231) J Lipid Res. 2002 Jun;43(6):986-9. (PMID: 12032175) J Gerontol A Biol Sci Med Sci. 2010 Jan;65(1):31-40. (PMID: 19901018) |
| معلومات مُعتمدة: | DK075436-01 United States DK NIDDK NIH HHS; R01 AG019899 United States AG NIA NIH HHS; AG019899-06 United States AG NIA NIH HHS; P01 AG031736 United States AG NIA NIH HHS; R15 DK075436 United States DK NIDDK NIH HHS; 1P01AG031736-01A1 United States AG NIA NIH HHS |
| المشرفين على المادة: | 0 (Insulin) |
| تواريخ الأحداث: | Date Created: 20110929 Date Completed: 20130312 Latest Revision: 20211020 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC3448990 |
| DOI: | 10.1007/s11357-011-9304-7 |
| PMID: | 21953241 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1574-4647 |
|---|---|
| DOI: | 10.1007/s11357-011-9304-7 |