التفاصيل البيبلوغرافية
| العنوان: |
[The lethiferous journey of a bacterium--the research progress of secretion systems and effectors in Legionella pneumophila]. |
| المؤلفون: |
Lu YJ; School of Life Sciences, Sun Yat-sen University, Guangzhou, China. luyj@mail.sysu.edu.cn, Li XH, Zeng YL |
| المصدر: |
Yi chuan = Hereditas [Yi Chuan] 2011 Oct; Vol. 33 (10), pp. 1093-101. |
| نوع المنشور: |
English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: |
Chinese |
| بيانات الدورية: |
Publisher: Ke xue chu ban she Country of Publication: China NLM ID: 9436478 Publication Model: Print Cited Medium: Print ISSN: 0253-9772 (Print) Linking ISSN: 02539772 NLM ISO Abbreviation: Yi Chuan Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Beijing : Ke xue chu ban she, |
| مواضيع طبية MeSH: |
Bacterial Proteins/*physiology , Legionella pneumophila/*pathogenicity, Apoptosis ; Cell Cycle ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Legionella pneumophila/immunology ; Legionella pneumophila/metabolism ; Virulence |
| مستخلص: |
Legionella pneumophila is the intracellular bacterial pathogen that causes severe Legionnaires' disease and flu-like Pontiac fever. To accomplish successful aggression against hosts, L. pneumophila secrets more than 150 kinds of substrate effector proteins into host cells via its Type IVB secretion system. With the multiple functions of effectors, L. pneumophila evades effectively the defense systems of hosts, converts or adjusts intracellular vesicular transport of hosts, modifies or disguises its Legionella containing vacuole (LCV), modulates the cell cycle program and inhibits the apoptosis of host cells, and finally gains the comfortable intracellular replicative niche. Effectors can also help L. pneumophila escape from hosts cells after completing the proliferation.. L. pneumophila has became the distinct model for pathogen-host interaction research, and its secretion systems as well as the substrate effectors are attracting more and more attentions. Researching on T4BSS and effectors could not only help investigate the pathogenesis of intracellular bacterial pathogens, but also promote the comprehension about innate immune responses of hosts. This article reviews the progresses of L. pneumophila T4BSS and effectors, trying to demonstrate to the readers the cunning survival strategy and the delicate virulent machine of L. pneumophila. |
| المشرفين على المادة: |
0 (Bacterial Proteins) |
| تواريخ الأحداث: |
Date Created: 20111014 Date Completed: 20111129 Latest Revision: 20161020 |
| رمز التحديث: |
20231215 |
| PMID: |
21993284 |
| قاعدة البيانات: |
MEDLINE |
