دورية أكاديمية
Amino acid changes in hemagglutinin contribute to the replication of oseltamivir-resistant H1N1 influenza viruses.
| العنوان: | Amino acid changes in hemagglutinin contribute to the replication of oseltamivir-resistant H1N1 influenza viruses. |
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| المؤلفون: | Ginting TE; Center for Infectious Diseases, Graduate School of Medicine, Kobe University, Kobe, Hyogo, Japan., Shinya K, Kyan Y, Makino A, Matsumoto N, Kaneda S, Kawaoka Y |
| المصدر: | Journal of virology [J Virol] 2012 Jan; Vol. 86 (1), pp. 121-7. Date of Electronic Publication: 2011 Oct 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington Dc : American Society For Microbiology Original Publication: Baltimore, American Society for Microbiology. |
| مواضيع طبية MeSH: | Amino Acid Substitution*/drug effects , Drug Resistance, Viral*/drug effects , Virus Replication*/drug effects, Antiviral Agents/*pharmacology , Hemagglutinin Glycoproteins, Influenza Virus/*genetics , Influenza A Virus, H1N1 Subtype/*physiology , Influenza, Human/*virology , Oseltamivir/*pharmacology, Amino Acid Sequence ; Animals ; Cell Line ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry ; Hemagglutinin Glycoproteins, Influenza Virus/metabolism ; Humans ; Influenza A Virus, H1N1 Subtype/classification ; Influenza A Virus, H1N1 Subtype/drug effects ; Influenza A Virus, H1N1 Subtype/genetics ; Molecular Sequence Data ; Mutation, Missense ; Neuraminidase/genetics ; Neuraminidase/metabolism ; Phylogeny ; Sequence Alignment ; Viral Proteins/genetics ; Viral Proteins/metabolism |
| مستخلص: | Oseltamivir-resistant H1N1 influenza viruses emerged in 2007 to 2008 and have subsequently circulated widely. However, prior to 2007 to 2008, viruses possessing the neuraminidase (NA) H274Y mutation, which confers oseltamivir resistance, generally had low growth capability. NA mutations that compensate for the deleterious effect of the NA H274Y mutation have since been identified. Given the importance of the functional balance between hemagglutinin (HA) and NA, we focused on amino acid changes in HA. Reverse genetic analysis showed that a mutation at residue 82, 141, or 189 of the HA protein promotes virus replication in the presence of the NA H274Y mutation. Our findings thus identify HA mutations that contributed to the replacement of the oseltamivir-sensitive viruses of 2007 to 2008. |
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| المشرفين على المادة: | 0 (Antiviral Agents) 0 (H1N1 virus hemagglutinin) 0 (Hemagglutinin Glycoproteins, Influenza Virus) 0 (Viral Proteins) 20O93L6F9H (Oseltamivir) EC 3.2.1.18 (NA protein, influenza A virus) EC 3.2.1.18 (Neuraminidase) |
| تواريخ الأحداث: | Date Created: 20111021 Date Completed: 20120214 Latest Revision: 20240417 |
| رمز التحديث: | 20240417 |
| مُعرف محوري في PubMed: | PMC3255889 |
| DOI: | 10.1128/JVI.06085-11 |
| PMID: | 22013054 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-5514 |
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| DOI: | 10.1128/JVI.06085-11 |