دورية أكاديمية
The antioxidant properties of different phthalocyanines.
| العنوان: | The antioxidant properties of different phthalocyanines. |
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| المؤلفون: | Amaral GP; Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus UFSM, 97105-900 Santa Maria, RS, Brazil., Puntel GO, Dalla Corte CL, Dobrachinski F, Barcelos RP, Bastos LL, Avila DS, Rocha JB, da Silva EO, Puntel RL, Soares FA |
| المصدر: | Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2012 Feb; Vol. 26 (1), pp. 125-32. Date of Electronic Publication: 2011 Oct 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 8712158 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3177 (Electronic) Linking ISSN: 08872333 NLM ISO Abbreviation: Toxicol In Vitro Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1987- |
| مواضيع طبية MeSH: | Antioxidants/*pharmacology , Indoles/*pharmacology , Lipid Peroxidation/*drug effects , Organometallic Compounds/*pharmacology, Animals ; Brain/drug effects ; Brain/metabolism ; Ferrous Compounds/pharmacology ; Hydrogen Peroxide/pharmacology ; Isoindoles ; Kidney/drug effects ; Kidney/metabolism ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Nitric Oxide Donors/pharmacology ; Nitroprusside/pharmacology ; Oxidants/pharmacology ; Oxidative Stress/drug effects |
| مستخلص: | Oxidative stress is involved in the etiology of several chronic diseases, including cardiovascular disease, diabetes, cancer, and neurodegenerative disorders. From this perspective, we have evaluated the possible antioxidant capacities of five different phthalocyanines (PCs), consisting of four metallophthalocyanines (MPCs) and one simple phthalocyanine (PC) in order to explore, for the first time, the potential antioxidant activities of these compounds. Our results show that all PCs tested in this study have significant antioxidant activity in lipid peroxidation assay, providing protection from sodium nitroprusside -induced oxidative damage to supernatant from the homogenized liver, brain, e rim of mice. Compared to the non-induced control, the PCs were generally more efficient in reducing malondialdehyde levels in all assays on lipid peroxidation induced by sodium nitroprusside; the order of approximate decrease in efficiency was as follows: manganese-PC (better efficiency)>copper-PC>iron-PC>zinc-PC>PC (worst efficiency). Furthermore, the copper-PC and manganese-PC compounds exerted a significant protective effect in deoxyribose degradation assays, when employing Fe(2+), Fe(2+)+H(2)O(2), and H(2)O(2) solutions. In conclusion, all PCs tested here were shown to be promising compounds for future in vivo investigations, because of their potential antioxidant activities in vitro. (Copyright © 2011 Elsevier Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Ferrous Compounds) 0 (Indoles) 0 (Isoindoles) 0 (Nitric Oxide Donors) 0 (Organometallic Compounds) 0 (Oxidants) 169D1260KM (Nitroprusside) 39R4TAN1VT (ferrous sulfate) BBX060AN9V (Hydrogen Peroxide) V5PUF4VLGY (phthalocyanine) |
| تواريخ الأحداث: | Date Created: 20111026 Date Completed: 20120503 Latest Revision: 20211203 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.tiv.2011.10.006 |
| PMID: | 22024102 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3177 |
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| DOI: | 10.1016/j.tiv.2011.10.006 |